4-(3-chloro-2-fluoro-phenylamino)-7-(2-methylsulfanyl-ethoxy)-quinazolin-6-ol

Base Information

Chemical Name:4-(3-chloro-2-fluoro-phenylamino)-7-(2-methylsulfanyl-ethoxy)-quinazolin-6-ol
CAS No.:870152-49-1
Molecular Formula:C₁₇H₁₅ClFN₃O₂S
Molecular Weight:379.842
Hs Code.:

Synonyms:4-(3-chloro-2-fluoro-phenylamino)-7-(2-methylsulfanyl-ethoxy)-quinazolin-6-ol

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Chemical Property of 4-(3-chloro-2-fluoro-phenylamino)-7-(2-methylsulfanyl-ethoxy)-quinazolin-6-ol

Chemical Property:

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Technology Process of 4-(3-chloro-2-fluoro-phenylamino)-7-(2-methylsulfanyl-ethoxy)-quinazolin-6-ol

There total 7 articles about 4-(3-chloro-2-fluoro-phenylamino)-7-(2-methylsulfanyl-ethoxy)-quinazolin-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 870152-49-1
4-(3-chloro-2-fluoro-phenylamino)-7-(2-methylsulfanyl-ethoxy)-quinazolin-6-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / propan-2-ol / Heating

2: 67 percent / pyridine hydrochloride / 3 h / 150 °C

3: 56 percent / triethylamine / tetrahydrofuran / 0 - 20 °C

4: 80 percent Chromat_. / DTAD; polystyrene-supported triphenylphosphine / CH₂Cl₂ / 1 h / 0 - 20 °C

5: 70 percent Chromat_. / NH₃ / methanol / 5 h / 20 °C

With polystyrene-supported triphenylphosphine; ammonia; pyridine hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol; 4: Mitsunobu alkylation;
DOI:10.1016/j.tetlet.2005.09.038

Reference yield:

: 870152-46-8
2,2-dimethyl-propionic acid 4-(3-chloro-2-fluoro-phenylamino)-7-(2-methylsulfanyl-ethoxy)-quinazolin-6-yl ester

: 870152-49-1
4-(3-chloro-2-fluoro-phenylamino)-7-(2-methylsulfanyl-ethoxy)-quinazolin-6-ol

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 5h;
DOI:10.1016/j.tetlet.2005.09.038

Reference yield:

: 848440-15-3
4-(3-chloro-2-fluoroanilino)-6,7-dihydroxyquinazoline

: 870152-49-1
4-(3-chloro-2-fluoro-phenylamino)-7-(2-methylsulfanyl-ethoxy)-quinazolin-6-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / triethylamine / tetrahydrofuran / 0 - 20 °C

2: 80 percent Chromat_. / DTAD; polystyrene-supported triphenylphosphine / CH₂Cl₂ / 1 h / 0 - 20 °C

3: 70 percent Chromat_. / NH₃ / methanol / 5 h / 20 °C

With polystyrene-supported triphenylphosphine; ammonia; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 2: Mitsunobu alkylation;
DOI:10.1016/j.tetlet.2005.09.038