[7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-(3-dimethylamino-pyrrolidin-1-yl)-methanone

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Chemical Name:[7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-(3-dimethylamino-pyrrolidin-1-yl)-methanone
CAS No.:952202-51-6
Molecular Formula:C₂₀H₂₃N₇O₃
Molecular Weight:409.448
Hs Code.:

Synonyms:[7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-(3-dimethylamino-pyrrolidin-1-yl)-methanone

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Chemical Property of [7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-(3-dimethylamino-pyrrolidin-1-yl)-methanone

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Technology Process of [7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-(3-dimethylamino-pyrrolidin-1-yl)-methanone

There total 3 articles about [7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-(3-dimethylamino-pyrrolidin-1-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 543683-45-0
2-(2-methyl-4-nitrophenyl)acetonitrile

: 952202-51-6
[7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-(3-dimethylamino-pyrrolidin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 12 h / 20 - 120 °C

2.1: hydrogenchloride; acetic acid / ethanol / 5.5 h / Heating / reflux

3.1: sodium hydroxide; ethanol; water / 6.5 h / Heating / reflux

3.2: 0 °C

4.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / dmap / N,N-dimethyl-formamide / 17 h / 20 °C

With hydrogenchloride; sodium hydroxide; ethanol; water; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; dmap; In ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: (Z)-3-dimethylamino-2-(3-methyl-4-nitro-phenyl)-acrylonitrile

: 952202-51-6
[7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-(3-dimethylamino-pyrrolidin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; acetic acid / ethanol / 5.5 h / Heating / reflux

2.1: sodium hydroxide; ethanol; water / 6.5 h / Heating / reflux

2.2: 0 °C

3.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / dmap / N,N-dimethyl-formamide / 17 h / 20 °C

With hydrogenchloride; sodium hydroxide; ethanol; water; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; dmap; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 952202-53-8
C₁₆H₁₅N₅O₄

: 952202-51-6
[7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-(3-dimethylamino-pyrrolidin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; ethanol; water / 6.5 h / Heating / reflux

1.2: 0 °C

2.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / dmap / N,N-dimethyl-formamide / 17 h / 20 °C

With sodium hydroxide; ethanol; water; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; dmap; In N,N-dimethyl-formamide;