6'-(2-hydroxy-propanol)-2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-3''-Boc-sisomicin

Base Information

Chemical Name:6'-(2-hydroxy-propanol)-2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-3''-Boc-sisomicin
CAS No.:1154759-12-2
Molecular Formula:C₅₅H₇₃N₉O₂₅
Molecular Weight:1260.23
Hs Code.:

Synonyms:6'-(2-hydroxy-propanol)-2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-3''-Boc-sisomicin

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Chemical Property of 6'-(2-hydroxy-propanol)-2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-3''-Boc-sisomicin

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Technology Process of 6'-(2-hydroxy-propanol)-2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-3''-Boc-sisomicin

There total 8 articles about 6'-(2-hydroxy-propanol)-2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-3''-Boc-sisomicin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23147-59-3
D,L-glyceraldehyde dimer

: 2',3-diPNZ-1-(N-PNZ-4-amino-2(R)-hydroxy-butyryl)-3''-boc-sisomicin trifluoroacetic acid salt

: 1154759-12-2
6'-(2-hydroxy-propanol)-2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-3''-Boc-sisomicin

Guidance literature:: D,L-glyceraldehyde dimer; 2',3-diPNZ-1-(N-PNZ-4-amino-2(R)-hydroxy-butyryl)-3''-boc-sisomicin trifluoroacetic acid salt; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 6h;

With sodium cyanoborohydride; acetic acid; In methanol; N,N-dimethyl-formamide; for 0.0833333h;

Reference yield:

: 4457-32-3
4-nitrobenzyl chloroformate

: 1154759-12-2
6'-(2-hydroxy-propanol)-2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-3''-Boc-sisomicin

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / water

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h

3.1: N,N-dimethyl-formamide

4.1: N-ethyl-N,N-diisopropylamine / methanol / 0 - 20 °C

5.1: methanol; ammonia; water

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h

6.2: 0.08 h

With methanol; ammonia; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 32385-11-8
sisomicin

: 1154759-12-2
6'-(2-hydroxy-propanol)-2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-3''-Boc-sisomicin

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc diacetate / methanol

1.2: 3 h

2.1: N,N-dimethyl-formamide

3.1: N-ethyl-N,N-diisopropylamine / methanol / 0 - 20 °C

4.1: methanol; ammonia; water

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h

5.2: 0.08 h

With methanol; zinc diacetate; ammonia; water; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;