(R)-2-Benzyloxy-2-((1S,2S,5R)-7-methyl-6-oxa-3,7-diaza-bicyclo[3.2.1]oct-2-yl)-ethanol

Base Information

Chemical Name:(R)-2-Benzyloxy-2-((1S,2S,5R)-7-methyl-6-oxa-3,7-diaza-bicyclo[3.2.1]oct-2-yl)-ethanol
CAS No.:423158-02-5
Molecular Formula:C₁₅H₂₂N₂O₃
Molecular Weight:278.351
Hs Code.:

Synonyms:(R)-2-Benzyloxy-2-((1S,2S,5R)-7-methyl-6-oxa-3,7-diaza-bicyclo[3.2.1]oct-2-yl)-ethanol

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Chemical Property of (R)-2-Benzyloxy-2-((1S,2S,5R)-7-methyl-6-oxa-3,7-diaza-bicyclo[3.2.1]oct-2-yl)-ethanol

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Technology Process of (R)-2-Benzyloxy-2-((1S,2S,5R)-7-methyl-6-oxa-3,7-diaza-bicyclo[3.2.1]oct-2-yl)-ethanol

There total 6 articles about (R)-2-Benzyloxy-2-((1S,2S,5R)-7-methyl-6-oxa-3,7-diaza-bicyclo[3.2.1]oct-2-yl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 423157-99-7
(1S,2S,3R,7R)-3-Benzyloxy-9-methyl-8-oxa-5,9-diaza-tricyclo[5.2.1.0^2,5]decan-4-one

: 423158-02-5
(R)-2-Benzyloxy-2-((1S,2S,5R)-7-methyl-6-oxa-3,7-diaza-bicyclo[3.2.1]oct-2-yl)-ethanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 0.333333h;
DOI:10.1055/s-2002-19333

Reference yield:

: 19810-31-2
Benzyloxyacetyl chloride

: 423158-02-5
(R)-2-Benzyloxy-2-((1S,2S,5R)-7-methyl-6-oxa-3,7-diaza-bicyclo[3.2.1]oct-2-yl)-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / Et₃N / CH₂Cl₂ / 16 h / 0 - 20 °C

2: p-TsOH*H₂O / tetrahydrofuran; H₂O / 2 h / Heating

3: 773 mg / sodium periodate / CH₂Cl₂

4: 70 percent / NEt₃ / toluene / 0.5 h / Heating

5: 100 percent / LiAlH₄ / diethyl ether / 1 h / 20 °C

With sodium periodate; lithium aluminium tetrahydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene; 1: Staudinger reaction;
DOI:10.1002/ejoc.200400792

Reference yield:

: 253599-41-6
(+)-(3R,4R)-3-benzyloxy-1-(2-propenyl)-4-oxoazetidine-2-carbaldehyde

: 423158-02-5
(R)-2-Benzyloxy-2-((1S,2S,5R)-7-methyl-6-oxa-3,7-diaza-bicyclo[3.2.1]oct-2-yl)-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / NEt₃ / toluene / 0.5 h / Heating

2: 100 percent / LiAlH₄ / diethyl ether / 1 h / 20 °C

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; toluene;
DOI:10.1002/ejoc.200400792