(R)-3-((R)-4-benzyl-2-oxazolidine-3-carbonyl)pentanedioic acid allyl ester

Base Information

Chemical Name:(R)-3-((R)-4-benzyl-2-oxazolidine-3-carbonyl)pentanedioic acid allyl ester
CAS No.:1424401-67-1
Molecular Formula:C₁₉H₂₁NO₇
Molecular Weight:375.378
Hs Code.:

Synonyms:(R)-3-((R)-4-benzyl-2-oxazolidine-3-carbonyl)pentanedioic acid allyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-((R)-4-benzyl-2-oxazolidine-3-carbonyl)pentanedioic acid allyl ester

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Technology Process of (R)-3-((R)-4-benzyl-2-oxazolidine-3-carbonyl)pentanedioic acid allyl ester

There total 6 articles about (R)-3-((R)-4-benzyl-2-oxazolidine-3-carbonyl)pentanedioic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1424401-64-8
(R)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)pentanedioic acid 1-allyl ester 5-tert-butyl ester

: 1424401-67-1
(R)-3-((R)-4-benzyl-2-oxazolidine-3-carbonyl)pentanedioic acid allyl ester

Guidance literature:: With trifluoroacetic acid; In tetrahydrofuran; dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm301346z

Reference yield:

: 1424401-65-9
(S)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)pentanedioic acid 1-allyl ester 5-tert-butyl ester

: 1424401-67-1
(R)-3-((R)-4-benzyl-2-oxazolidine-3-carbonyl)pentanedioic acid allyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm301346z

Reference yield:

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 1424401-67-1
(R)-3-((R)-4-benzyl-2-oxazolidine-3-carbonyl)pentanedioic acid allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 64 h / 20 °C / Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.5 h / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / tetrahydrofuran; dichloromethane / 16 h / 20 °C / Inert atmosphere

With n-butyllithium; sodium hexamethyldisilazane; potassium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm301346z