4-(2-cyclohexylmethylaminoethoxy)-7-fluoro-3-thiomethyl-1,3-dihydroindol-2-one

Base Information

Chemical Name:4-(2-cyclohexylmethylaminoethoxy)-7-fluoro-3-thiomethyl-1,3-dihydroindol-2-one
CAS No.:203922-24-1
Molecular Formula:C₁₈H₂₅FN₂O₂S
Molecular Weight:352.473
Hs Code.:

Synonyms:4-(2-cyclohexylmethylaminoethoxy)-7-fluoro-3-thiomethyl-1,3-dihydroindol-2-one

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Chemical Property of 4-(2-cyclohexylmethylaminoethoxy)-7-fluoro-3-thiomethyl-1,3-dihydroindol-2-one

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Technology Process of 4-(2-cyclohexylmethylaminoethoxy)-7-fluoro-3-thiomethyl-1,3-dihydroindol-2-one

There total 6 articles about 4-(2-cyclohexylmethylaminoethoxy)-7-fluoro-3-thiomethyl-1,3-dihydroindol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 3218-02-8
cyclohexylmethylamine

: 203922-22-9
4-(2-chloroethoxy)-7-fluoro-3-thiomethyl-1,3-dihydroindol-2-one

: 203922-24-1
4-(2-cyclohexylmethylaminoethoxy)-7-fluoro-3-thiomethyl-1,3-dihydroindol-2-one

Guidance literature:: In dimethyl sulfoxide; at 80 ℃; for 6h;
DOI:10.1021/jm990023s

Reference yield:

: 371-41-5
4-Fluorophenol

: 203922-24-1
4-(2-cyclohexylmethylaminoethoxy)-7-fluoro-3-thiomethyl-1,3-dihydroindol-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / Br₂ / acetic acid / 1 h / Ambient temperature

2: 97 percent / K₂CO₃ / butan-2-one / 2 h / Heating

3: 97 percent / conc. aq. H₂SO₄, HNO₃ / 1 h / Ambient temperature

4: 90 percent / H₂ / 10 percent Pd/C / ethanol / 24 h / 2068.59 Torr

5: 1.) sulfur chloride, 2.) Proton Sponge, 3.) Et₃N

6: 48 percent / dimethylsulfoxide / 6 h / 80 °C

With Proton Sponge; sulfuric acid; sulfur dichloride; hydrogen; bromine; nitric acid; potassium carbonate; triethylamine; palladium on activated charcoal; In ethanol; acetic acid; dimethyl sulfoxide; butanone;
DOI:10.1021/jm990023s

Reference yield:

: 344-20-7
2,6-dibromo-4-fluorophenol

: 203922-24-1
4-(2-cyclohexylmethylaminoethoxy)-7-fluoro-3-thiomethyl-1,3-dihydroindol-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / K₂CO₃ / butan-2-one / 2 h / Heating

2: 97 percent / conc. aq. H₂SO₄, HNO₃ / 1 h / Ambient temperature

3: 90 percent / H₂ / 10 percent Pd/C / ethanol / 24 h / 2068.59 Torr

4: 1.) sulfur chloride, 2.) Proton Sponge, 3.) Et₃N

5: 48 percent / dimethylsulfoxide / 6 h / 80 °C

With Proton Sponge; sulfuric acid; sulfur dichloride; hydrogen; nitric acid; potassium carbonate; triethylamine; palladium on activated charcoal; In ethanol; dimethyl sulfoxide; butanone;
DOI:10.1021/jm990023s