2-(2-(4-chloro-2-hydroxybenzylidene)hydrazinyl)-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazin-3(4H)-one

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Chemical Name:2-(2-(4-chloro-2-hydroxybenzylidene)hydrazinyl)-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazin-3(4H)-one
CAS No.:1359965-15-3
Molecular Formula:C₂₁H₁₃ClF₃N₅O₃
Molecular Weight:475.814
Hs Code.:

Synonyms:2-(2-(4-chloro-2-hydroxybenzylidene)hydrazinyl)-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazin-3(4H)-one

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Chemical Property of 2-(2-(4-chloro-2-hydroxybenzylidene)hydrazinyl)-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazin-3(4H)-one

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Technology Process of 2-(2-(4-chloro-2-hydroxybenzylidene)hydrazinyl)-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazin-3(4H)-one

There total 7 articles about 2-(2-(4-chloro-2-hydroxybenzylidene)hydrazinyl)-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 2420-26-0
4-chlorosalicylaldehyde

: 1333931-11-5
2-hydrazinyl-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazin-3(4H)-one

: 1359965-15-3
2-(2-(4-chloro-2-hydroxybenzylidene)hydrazinyl)-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazin-3(4H)-one

Guidance literature:: In ethanol; at 20 - 60 ℃; for 5h;
DOI:10.1002/ardp.201100103

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 1359965-15-3
2-(2-(4-chloro-2-hydroxybenzylidene)hydrazinyl)-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazin-3(4H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / isopropyl alcohol / 9 h / 20 °C / Reflux

2: ammonium chloride; zinc / ethanol / 6 h / 20 °C / Reflux

3: hydrogenchloride / water / 15 h / Reflux

4: N,N-dimethyl-formamide; trichlorophosphate / acetonitrile / 3 h / 80 °C

5: hydrazine hydrate / 1 h / 60 °C

6: ethanol / 5 h / 20 - 60 °C

With hydrogenchloride; ammonium chloride; hydrazine hydrate; triethylamine; N,N-dimethyl-formamide; zinc; trichlorophosphate; In ethanol; water; isopropyl alcohol; acetonitrile;
DOI:10.1002/ardp.201100103

Reference yield:

: 1333931-08-0
3-nitro-N-(4-(trifluoromethoxy)phenyl)pyridin-2-amine

: 1359965-15-3
2-(2-(4-chloro-2-hydroxybenzylidene)hydrazinyl)-4-(4-(trifluoromethoxy)phenyl)pyrido[2,3-b]pyrazin-3(4H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium chloride; zinc / ethanol / 6 h / 20 °C / Reflux

2: hydrogenchloride / water / 15 h / Reflux

3: N,N-dimethyl-formamide; trichlorophosphate / acetonitrile / 3 h / 80 °C

4: hydrazine hydrate / 1 h / 60 °C

5: ethanol / 5 h / 20 - 60 °C

With hydrogenchloride; ammonium chloride; hydrazine hydrate; N,N-dimethyl-formamide; zinc; trichlorophosphate; In ethanol; water; acetonitrile;
DOI:10.1002/ardp.201100103