2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-ylpyrimidine trifluoroacetic acid salt

Base Information

Chemical Name:2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-ylpyrimidine trifluoroacetic acid salt
CAS No.:869891-39-4
Molecular Formula:C₂HF₃O₂*C₂₀H₂₇ClN₄O
Molecular Weight:488.938
Hs Code.:

Synonyms:2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-ylpyrimidine trifluoroacetic acid salt

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Chemical Property of 2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-ylpyrimidine trifluoroacetic acid salt

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Technology Process of 2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-ylpyrimidine trifluoroacetic acid salt

There total 3 articles about 2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-ylpyrimidine trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869891-37-2
4-[2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-6-methyl-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 869891-39-4
2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-ylpyrimidine trifluoroacetic acid salt

Guidance literature:: In dichloromethane; for 0.333333h;

Reference yield:

: 626-48-2
6-Methyluracil

: 869891-39-4
2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-ylpyrimidine trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water / 0.17 h / 20 °C

1.2: 3 h

2.1: tributyl-amine / trichlorophosphate / 7 h / 90 °C / Heating / reflux

3.1: potassium tert-butylate / tetrahydrofuran; ISOPROPYLAMIDE / 40.33 h / 0 - 20 °C

4.1: potassium carbonate / ISOPROPYLAMIDE / 16 h / 20 °C

5.1: dichloromethane / 0.33 h

With sodium hydroxide; tributyl-amine; potassium tert-butylate; potassium carbonate; In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE; water; trichlorophosphate;

Reference yield:

: 147-61-5
5-hydroxymethyl-6-methyl-1H-pyrimidine-2,4-dione

: 869891-39-4
2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-ylpyrimidine trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1: tributyl-amine / trichlorophosphate / 7 h / 90 °C / Heating / reflux

2: potassium tert-butylate / tetrahydrofuran; ISOPROPYLAMIDE / 40.33 h / 0 - 20 °C

3: potassium carbonate / ISOPROPYLAMIDE / 16 h / 20 °C

4: dichloromethane / 0.33 h

With tributyl-amine; potassium tert-butylate; potassium carbonate; In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE; trichlorophosphate;