rac-3-{[(3-tert-butoxycarbonyl-propyl)-(2-oxo-1,2,3,4-tetrahydro-quinoline-4-carbonyl)-amino]-methyl}-4-(3,5-difluoro-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:rac-3-{[(3-tert-butoxycarbonyl-propyl)-(2-oxo-1,2,3,4-tetrahydro-quinoline-4-carbonyl)-amino]-methyl}-4-(3,5-difluoro-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:960006-23-9
Molecular Formula:C₃₅H₄₅F₂N₃O₆
Molecular Weight:641.756
Hs Code.:

rac-3-{[(3-tert-butoxycarbonyl-propyl)-(2-oxo-1,2,3,4-tetrahydro-quinoline-4-carbonyl)-amino]-methyl}-4-(3,5-difluoro-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Synonyms:rac-3-{[(3-tert-butoxycarbonyl-propyl)-(2-oxo-1,2,3,4-tetrahydro-quinoline-4-carbonyl)-amino]-methyl}-4-(3,5-difluoro-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of rac-3-{[(3-tert-butoxycarbonyl-propyl)-(2-oxo-1,2,3,4-tetrahydro-quinoline-4-carbonyl)-amino]-methyl}-4-(3,5-difluoro-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of rac-3-{[(3-tert-butoxycarbonyl-propyl)-(2-oxo-1,2,3,4-tetrahydro-quinoline-4-carbonyl)-amino]-methyl}-4-(3,5-difluoro-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 3 articles about rac-3-{[(3-tert-butoxycarbonyl-propyl)-(2-oxo-1,2,3,4-tetrahydro-quinoline-4-carbonyl)-amino]-methyl}-4-(3,5-difluoro-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 960006-22-8
rac-3-[(3-tert-butoxycarbonyl-propylamino)-methyl]-4-(3,5-difluoro-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 14179-84-1
2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid

: 960006-23-9
rac-3-{[(3-tert-butoxycarbonyl-propyl)-(2-oxo-1,2,3,4-tetrahydro-quinoline-4-carbonyl)-amino]-methyl}-4-(3,5-difluoro-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 40 ℃; for 0.5h;

Reference yield:

: 960006-20-6
rac-4-(3,5-difluoro-benzyl)-pyrrolidine-3-carbonitrile

: 960006-23-9
rac-3-{[(3-tert-butoxycarbonyl-propyl)-(2-oxo-1,2,3,4-tetrahydro-quinoline-4-carbonyl)-amino]-methyl}-4-(3,5-difluoro-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 2 h / -78 °C

2.1: triethylamine / 1,2-dichloro-ethane / 0.08 h

2.2: 1 h / 20 °C

3.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 0.5 h / 40 °C

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 960006-21-7
rac-3-(3,5-difluoro-benzyl)-4-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: tert-butyl 4-aminobutanoate hydrochloride

: 960006-23-9
rac-3-{[(3-tert-butoxycarbonyl-propyl)-(2-oxo-1,2,3,4-tetrahydro-quinoline-4-carbonyl)-amino]-methyl}-4-(3,5-difluoro-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / 1,2-dichloro-ethane / 0.08 h

1.2: 1 h / 20 °C

2.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 0.5 h / 40 °C

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; 1,2-dichloro-ethane;