1-[(tert-butyldimethylsilyl)oxy]-1-[5-(2-oxazolyl)oxazol-2-yl]-7-phenylheptane

Base Information

• Chemical Name: 1-[(tert-butyldimethylsilyl)oxy]-1-[5-(2-oxazolyl)oxazol-2-yl]-7-phenylheptane
• CAS No.: 808135-12-8
• Molecular Formula: C₂₅H₃₆N₂O₃Si
• Molecular Weight: 440.658
• Mol file: 808135-12-8.mol

Synonyms:1-[(tert-butyldimethylsilyl)oxy]-1-[5-(2-oxazolyl)oxazol-2-yl]-7-phenylheptane

Chemical Property of 1-[(tert-butyldimethylsilyl)oxy]-1-[5-(2-oxazolyl)oxazol-2-yl]-7-phenylheptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(tert-butyldimethylsilyl)oxy]-1-[5-(2-oxazolyl)oxazol-2-yl]-7-phenylheptane

There total 4 articles about 1-[(tert-butyldimethylsilyl)oxy]-1-[5-(2-oxazolyl)oxazol-2-yl]-7-phenylheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1-[(tert-butyldimethylsilyl)oxy]-1-(5-iodooxazol-2-yl)-7-phenylheptane (808134-97-6) + 2-(tributyltin)oxazole (145214-05-7) → 1-[(tert-butyldimethylsilyl)oxy]-1-[5-(2-oxazolyl)oxazol-2-yl]-7-phenylheptane (808135-12-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃;

DOI:10.1021/jm049614v

Reference yield:

1-(oxazol-2-yl)-7-phenylheptan-1-ol (808134-95-4) → 1-[(tert-butyldimethylsilyl)oxy]-1-[5-(2-oxazolyl)oxazol-2-yl]-7-phenylheptane (808135-12-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 100 percent / imidazole / dimethylformamide / 20 °C

2.1: t-BuLi / tetrahydrofuran / 2 h / -40 °C

2.2: 89 percent / I₂ / tetrahydrofuran / -78 °C

3.1: 50 percent / Pd(PPh₃)4 / dioxane / 100 °C

With 1H-imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 3.1: Stille coupling;

DOI:10.1021/jm049614v

Reference yield:

1-[(tert-butyldimethylsilyl)oxy]-1-(oxazol-2-yl)-7-phenylheptane (808134-96-5) → 1-[(tert-butyldimethylsilyl)oxy]-1-[5-(2-oxazolyl)oxazol-2-yl]-7-phenylheptane (808135-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: t-BuLi / tetrahydrofuran / 2 h / -40 °C

1.2: 89 percent / I₂ / tetrahydrofuran / -78 °C

2.1: 50 percent / Pd(PPh₃)4 / dioxane / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; In tetrahydrofuran; 1,4-dioxane; 2.1: Stille coupling;

DOI:10.1021/jm049614v

upstream raw materials:

1-[(tert-butyldimethylsilyl)oxy]-1-(5-iodooxazol-2-yl)-7-phenylheptane

2-(tributyltin)oxazole

1-(oxazol-2-yl)-7-phenylheptan-1-ol

1-[(tert-butyldimethylsilyl)oxy]-1-(oxazol-2-yl)-7-phenylheptane

Downstream raw materials:

1-[5-(2-oxazolyl)oxazol-2-yl]-7-phenylheptan-1-ol