TETRAHYDROTHIOPYRAN-4-OL 97

Base Information

• Chemical Name: TETRAHYDROTHIOPYRAN-4-OL 97
• CAS No.: 29683-23-6
• Molecular Formula: C5H10OS
• Molecular Weight: 118.2
• Hs Code.: 2934999090
• Mol file: 29683-23-6.mol

Synonyms:Thiopyran-4-ol,tetrahydro- (6CI,7CI);4-Hydroxy-1-thiacyclohexane;4-Hydroxytetrahydrothiopyran;4-Hydroxythiane;4-Tetrahydrothiapyranol;Tetrahydro-2H-thiopyran-4-ol;Tetrahydrothiopyran-4-ol;Thiacyclohexan-4-ol;

Chemical Property of TETRAHYDROTHIOPYRAN-4-OL 97

Chemical Property:

• Vapor Pressure: 0.026mmHg at 25°C
• Melting Point: 47-51 °C(lit.)
• Refractive Index: 1.55
• Boiling Point: 218.8 °C at 760 mmHg
• PKA: 14.56±0.20(Predicted)
• Flash Point: 107.2 °C
• PSA: 45.53000
• Density: 1.148 g/cm³
• LogP: 0.87430
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Tetrahydro-2H-thiopyran-4-O ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TETRAHYDROTHIOPYRAN-4-OL 97

There total 1 articles about TETRAHYDROTHIOPYRAN-4-OL 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Tetrahydrothiopyran-4-one (1072-72-6) + O-benzyl carbamate (621-84-1) → tetrahydrothiopyran-4-ol (29683-23-6) + benzyl (tetrahydro-2H-thiopyran-4-yl)carbamate (402927-98-4)

Guidance literature:

With triethylsilane; sodium hexaflorophosphate; perrhenic acid anhydride; In dichloromethane; at 50 ℃; for 48h; chemoselective reaction;

DOI:10.1039/c3ob40918j

Reference yield: 100.0%

tetrahydrothiopyran-4-ol (29683-23-6) + tert-butyl 3-(2-fluoro-4-{[(4'-hydroxy-2',6'-dimethylbiphenyl-3-yl)methyl][(2-nitrophenyl)sulfonyl]amino}phenyl)propanoate (865135-75-7) → tert-butyl 3-[4-({[2',6'-dimethyl-4'-(tetrahydro-2H-thiopyran-4-yloxy)biphenyl-3-yl]methyl}[(2-nitrophenyl)sulfonyl]amino)-2-fluorophenyl]propanoate (865136-47-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm2016123

Reference yield: 99.0%

tetrahydrothiopyran-4-ol (29683-23-6) + 1-bromomethyl-4-bromobenzene (589-15-1) → 4-((4-bromobenzyl)oxy)tetrahydro-2H-thiopyran

Guidance literature:

tetrahydrothiopyran-4-ol; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

1-bromomethyl-4-bromobenzene; In tetrahydrofuran; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.202103428

upstream raw materials:

Tetrahydrothiopyran-4-one

O-benzyl carbamate

Downstream raw materials:

diphenyl-acetic acid tetrahydrothiopyran-4-yl ester

cyclohexyl-phenyl-acetic acid tetrahydrothiopyran-4-yl ester

4-Acetoxythiacyclohexan

4-nitro-benzoic acid tetrahydrothiopyran-4-yl ester