trans-4-Cbz-aminocyclohexyl p-toluenesulphonate

Base Information

Chemical Name:trans-4-Cbz-aminocyclohexyl p-toluenesulphonate
CAS No.:29493-38-7
Molecular Formula:C21H25 N O5 S
Molecular Weight:403.499
Hs Code.:2924299090
European Community (EC) Number:660-031-6
DSSTox Substance ID:DTXSID00409175
Mol file:29493-38-7.mol

Synonyms:trans-4-Cbz-aminocyclohexyl p-toluenesulphonate;29493-38-7;[4-(phenylmethoxycarbonylamino)cyclohexyl] 4-methylbenzenesulfonate;DTXSID00409175;MFCD00159229;AKOS024434000;BENZYL N-(4-(P-TOSYLOXY)CYCLOHEXYL)CARBAMATE;(1r,4r)-4-(benzyloxycarbonylamino)cyclohexyl 4-methylbenzenesulfonate;4-{[(Benzyloxy)carbonyl]amino}cyclohexyl 4-methylbenzene-1-sulfonate

Suppliers and Price of trans-4-Cbz-aminocyclohexyl p-toluenesulphonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
BENZYL N-(4-(P-TOSYLOXY)CYCLOHEXYL)CARBAMATE 95.00%
5MG
$ 498.43

Total 7 raw suppliers

Chemical Property of trans-4-Cbz-aminocyclohexyl p-toluenesulphonate

Chemical Property:

Vapor Pressure:1.41E-13mmHg at 25°C
Refractive Index:1.595
Boiling Point:582.9°C at 760 mmHg
Flash Point:306.3°C
PSA：90.08000
Density:1.28g/cm³
LogP:5.40960
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:403.14534407
Heavy Atom Count:28
Complexity:580

Purity/Quality:

95% ^*data from raw suppliers

BENZYL N-(4-(P-TOSYLOXY)CYCLOHEXYL)CARBAMATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)OC2CCC(CC2)NC(=O)OCC3=CC=CC=C3

Technology Process of trans-4-Cbz-aminocyclohexyl p-toluenesulphonate

There total 4 articles about trans-4-Cbz-aminocyclohexyl p-toluenesulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 27489-63-0
trans-4-<(benzyloxycarbonyl)amino>cyclohexanol

: 98-59-9
p-toluenesulfonyl chloride

: 29493-38-7
trans-4-carbobenzoxyaminocyclohexyl p-toluenesulfonate

Guidance literature:: In pyridine; at 0 - 20 ℃; for 20h;
DOI:10.1021/ja036644z

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 29493-38-7
trans-4-carbobenzoxyaminocyclohexyl p-toluenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / aq. NaOH / 2 h / 0 °C

2: 97 percent / pyridine / 20 h / 0 - 20 °C

With sodium hydroxide; In pyridine;
DOI:10.1021/ja036644z

Reference yield:

: 27489-62-9
trans-4-hydroxycyclohexylamine

: 501-53-1,94274-21-2
benzyl chloroformate

: 29493-38-7
trans-4-carbobenzoxyaminocyclohexyl p-toluenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 3 h / 0 °C

2: pyridine / 14 h / 20 °C

With pyridine; sodium hydroxide; In water;
DOI:10.1002/chem.201101427