2-[(4-(4-chlorophenylamino)-5-cyano-6-phenylpyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide

Base Information

• Chemical Name: 2-[(4-(4-chlorophenylamino)-5-cyano-6-phenylpyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide
• CAS No.: 1382229-13-1
• Molecular Formula: C₃₄H₂₂Cl₃N₇O₃S
• Molecular Weight: 715.019
• Mol file: 1382229-13-1.mol

Synonyms:2-[(4-(4-chlorophenylamino)-5-cyano-6-phenylpyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide

Chemical Property of 2-[(4-(4-chlorophenylamino)-5-cyano-6-phenylpyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(4-(4-chlorophenylamino)-5-cyano-6-phenylpyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide

There total 5 articles about 2-[(4-(4-chlorophenylamino)-5-cyano-6-phenylpyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-((4-chloro-5-cyano-6-phenylpyrimidin-2-yl)sulfanyl)-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide (1382228-98-9) + 4-chloro-aniline (106-47-8) → 2-[(4-(4-chlorophenylamino)-5-cyano-6-phenylpyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide (1382229-13-1)

Guidance literature:

With triethylamine; In ethanol; at 20 ℃; for 29h; Reflux;

DOI:10.1016/j.ejmech.2012.03.050

Reference yield:

2-((5-cyano-6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl)-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide (1382228-52-5) → 2-[(4-(4-chlorophenylamino)-5-cyano-6-phenylpyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide (1382229-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 6.5 h / Cooling with ice; Reflux

2: triethylamine / ethanol / 29 h / 20 °C / Reflux

With triethylamine; trichlorophosphate; In ethanol;

DOI:10.1016/j.ejmech.2012.03.050

Reference yield:

2-[2-(2,4-dichlorophenoxy)acetylamino]benzoic acid methyl ester (303794-61-8) → 2-[(4-(4-chlorophenylamino)-5-cyano-6-phenylpyrimidin-2-yl)sulfanyl]-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide (1382229-13-1)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrazine hydrate / butan-1-ol / 10 h / Reflux

2: triethylamine / benzene / 4 h / Reflux

3: potassium carbonate / acetone / 6 h / Reflux

4: trichlorophosphate / 6.5 h / Cooling with ice; Reflux

5: triethylamine / ethanol / 29 h / 20 °C / Reflux

With potassium carbonate; hydrazine hydrate; triethylamine; trichlorophosphate; In ethanol; acetone; butan-1-ol; benzene;

DOI:10.1016/j.ejmech.2012.03.050

upstream raw materials:

2-[2-(2,4-dichlorophenoxy)acetylamino]benzoic acid methyl ester

2-((4-chloro-5-cyano-6-phenylpyrimidin-2-yl)sulfanyl)-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide

4-chloro-aniline

2-((5-cyano-6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl)-N-[2-(2,4-dichlorophenoxymethyl)-4-oxo-4H-quinazolin-3-yl]acetamide