5,5-difluoro-1,3-dimethyl-7-(3-(5-phenethyl-1H-1,2,3-triazol-1-yl)propyl)-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

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Chemical Name:5,5-difluoro-1,3-dimethyl-7-(3-(5-phenethyl-1H-1,2,3-triazol-1-yl)propyl)-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide
CAS No.:1451009-89-4
Molecular Formula:C₂₄H₂₆BF₂N₅
Molecular Weight:433.312
Hs Code.:

Synonyms:5,5-difluoro-1,3-dimethyl-7-(3-(5-phenethyl-1H-1,2,3-triazol-1-yl)propyl)-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

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Chemical Property of 5,5-difluoro-1,3-dimethyl-7-(3-(5-phenethyl-1H-1,2,3-triazol-1-yl)propyl)-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

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Technology Process of 5,5-difluoro-1,3-dimethyl-7-(3-(5-phenethyl-1H-1,2,3-triazol-1-yl)propyl)-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

There total 9 articles about 5,5-difluoro-1,3-dimethyl-7-(3-(5-phenethyl-1H-1,2,3-triazol-1-yl)propyl)-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16520-62-0
4-Phenyl-1-butyne

: 1451009-77-0
7-(3-azidopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

: 1451009-80-5
5,5-difluoro-1,3-dimethyl-7-(3-(4-phenethyl-1H-1,2,3-triazol-1-yl)propyl)-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

: 1451009-89-4
5,5-difluoro-1,3-dimethyl-7-(3-(5-phenethyl-1H-1,2,3-triazol-1-yl)propyl)-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 70 ℃; for 18h; Overall yield = 84 %; Overall yield = 60 mg; Inert atmosphere; Sealed tube;
DOI:10.1016/j.tet.2013.05.037

Reference yield:

: 69917-80-2
2-(2-methoxycarbonylethyl)-pyrrole

: 1451009-80-5
5,5-difluoro-1,3-dimethyl-7-(3-(4-phenethyl-1H-1,2,3-triazol-1-yl)propyl)-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

: 1451009-89-4
5,5-difluoro-1,3-dimethyl-7-(3-(5-phenethyl-1H-1,2,3-triazol-1-yl)propyl)-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

3.1: sodium azide / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

4.1: trichlorophosphate / dichloromethane / 0 - 20 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrahydrofuran / 18 h / 70 °C / Inert atmosphere; Sealed tube

With copper(l) iodide; lithium aluminium tetrahydride; sodium azide; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.05.037

Reference yield:

: 7699-48-1
3-(1H-pyrrol-2-yl)propan-1-ol

: 1451009-80-5
5,5-difluoro-1,3-dimethyl-7-(3-(4-phenethyl-1H-1,2,3-triazol-1-yl)propyl)-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

: 1451009-89-4
5,5-difluoro-1,3-dimethyl-7-(3-(5-phenethyl-1H-1,2,3-triazol-1-yl)propyl)-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.1: sodium azide / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

3.1: trichlorophosphate / dichloromethane / 0 - 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrahydrofuran / 18 h / 70 °C / Inert atmosphere; Sealed tube

With copper(l) iodide; sodium azide; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.05.037