3-{1-[4,4-bis(4-fluorophenyl)-1-butyl]-4-piperidyl}-6-fluoro-1,2-benzisoxazole

Base Information

Chemical Name:3-{1-[4,4-bis(4-fluorophenyl)-1-butyl]-4-piperidyl}-6-fluoro-1,2-benzisoxazole
CAS No.:84231-26-5
Molecular Formula:C₂₈H₂₇F₃N₂O
Molecular Weight:464.53
Hs Code.:

Synonyms:3-{1-[4,4-bis(4-fluorophenyl)-1-butyl]-4-piperidyl}-6-fluoro-1,2-benzisoxazole

Suppliers and Price of 3-{1-[4,4-bis(4-fluorophenyl)-1-butyl]-4-piperidyl}-6-fluoro-1,2-benzisoxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-{1-[4,4-bis(4-fluorophenyl)-1-butyl]-4-piperidyl}-6-fluoro-1,2-benzisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-{1-[4,4-bis(4-fluorophenyl)-1-butyl]-4-piperidyl}-6-fluoro-1,2-benzisoxazole

There total 4 articles about 3-{1-[4,4-bis(4-fluorophenyl)-1-butyl]-4-piperidyl}-6-fluoro-1,2-benzisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84163-13-3
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

: 3312-04-7
4-chloro-1,1-bis(4-fluorophenyl)butane

: 84231-26-5
3-{1-[4,4-bis(4-fluorophenyl)-1-butyl]-4-piperidyl}-6-fluoro-1,2-benzisoxazole

Guidance literature:: With sodium hydrogencarbonate; potassium iodide; In N,N-dimethyl-formamide; at 100 ℃; for 8h;
DOI:10.1021/jm00383a012

Reference yield:

: 84163-41-7
6-fluoro-3-(1-formyl-4-piperidinyl)-1,2-benzisoxazole

: 84231-26-5
3-{1-[4,4-bis(4-fluorophenyl)-1-butyl]-4-piperidyl}-6-fluoro-1,2-benzisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / ethanol / 3 h / Heating

2: NaHCO₃, KI / dimethylformamide / 8 h / 100 °C

With hydrogenchloride; sodium hydrogencarbonate; potassium iodide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00383a012

Reference yield:

: 84162-94-7
1-formyl-4-(2,4-difluorobenzoyl)piperidine oxime

: 84231-26-5
3-{1-[4,4-bis(4-fluorophenyl)-1-butyl]-4-piperidyl}-6-fluoro-1,2-benzisoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / dimethylformamide / 4 h / 70 - 75 °C

2: aq. HCl / ethanol / 3 h / Heating

3: NaHCO₃, KI / dimethylformamide / 8 h / 100 °C

With hydrogenchloride; sodium hydride; sodium hydrogencarbonate; potassium iodide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00383a012