2H-1,2,3-Benzodiazaphosphole, 2-acetyl-4,5,6,7-tetrahydro- (9CI)

Base Information

• Chemical Name: 2H-1,2,3-Benzodiazaphosphole, 2-acetyl-4,5,6,7-tetrahydro- (9CI)
• CAS No.: 137152-49-9
• Molecular Formula: C8H11N2OP
• Molecular Weight: 0
• Mol file: 137152-49-9.mol

Synonyms:2H-1,2,3-Benzodiazaphosphole, 2-acetyl-4,5,6,7-tetrahydro- (9CI)

Chemical Property of 2H-1,2,3-Benzodiazaphosphole, 2-acetyl-4,5,6,7-tetrahydro- (9CI)

Chemical Property:

• PSA: 66.81000
• LogP: 1.18560

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-1,2,3-Benzodiazaphosphole, 2-acetyl-4,5,6,7-tetrahydro- (9CI)

There total 2 articles about 2H-1,2,3-Benzodiazaphosphole, 2-acetyl-4,5,6,7-tetrahydro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-(3-Chloro-3,3a,4,5,6,7-hexahydro-benzo[1,2,3]diazaphosphol-2-yl)-ethanone (137152-46-6) → 1-(4,5,6,7-Tetrahydro-benzo[1,2,3]diazaphosphol-2-yl)-ethanone (137152-49-9)

Guidance literature:

With triethylamine; In benzene; for 8h;

DOI:10.1055/s-1991-26573

Reference yield:

1-acetyl-2-(1-cyclohexylidene)hydrazine (28766-50-9) → 1-(4,5,6,7-Tetrahydro-benzo[1,2,3]diazaphosphol-2-yl)-ethanone (137152-49-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 37 percent / phosphorus trichloride, triethylamine / CH₂Cl₂ / 6 h / Ambient temperature

2: 60 percent / triethylamine / benzene / 8 h

With triethylamine; phosphorus trichloride; In dichloromethane; benzene;

DOI:10.1055/s-1991-26573

Reference yield: 77.0%

1-(tert-Butyl-diphenyl-silanyl)-1-diazo-3,3-dimethyl-butan-2-one (110907-77-2) + 1-(4,5,6,7-Tetrahydro-benzo[1,2,3]diazaphosphol-2-yl)-ethanone (137152-49-9) → 5-acetyl-3-[(E)-1-(tert-butyldiphenylsiloxy)-2,2-dimethylpropylidene]-7,8,9,10-tetrahydro-3H,5H-benzo[d][1,2,4]diazaphospholo[4,3-c][1,2,3]diazaphosphole

Guidance literature:

In dichloromethane; at 20 ℃; for 14h;

DOI:10.1002/1099-0690(200104)2001:8<1581::AID-EJOC1581>3.0.CO;2-#

upstream raw materials:

1-(3-Chloro-3,3a,4,5,6,7-hexahydro-benzo[1,2,3]diazaphosphol-2-yl)-ethanone

1-acetyl-2-(1-cyclohexylidene)hydrazine