{(2R,4R)-2-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-ethoxy-tetrahydro-pyran-4-yl}-acetic acid ethyl ester

Base Information

Chemical Name:{(2R,4R)-2-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-ethoxy-tetrahydro-pyran-4-yl}-acetic acid ethyl ester
CAS No.:143521-70-4
Molecular Formula:C₃₀H₄₄O₅Si
Molecular Weight:512.762
Hs Code.:

Synonyms:{(2R,4R)-2-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-ethoxy-tetrahydro-pyran-4-yl}-acetic acid ethyl ester

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Chemical Property of {(2R,4R)-2-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-ethoxy-tetrahydro-pyran-4-yl}-acetic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of {(2R,4R)-2-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-ethoxy-tetrahydro-pyran-4-yl}-acetic acid ethyl ester

There total 6 articles about {(2R,4R)-2-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-ethoxy-tetrahydro-pyran-4-yl}-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 143521-60-2,143615-99-0
(E)-(5R,6R)-5-(2-Bromo-1-ethoxy-ethoxy)-7-(tert-butyl-diphenyl-silanyloxy)-6-methyl-hept-2-enoic acid ethyl ester

: 143521-70-4
{(2R,4R)-2-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-ethoxy-tetrahydro-pyran-4-yl}-acetic acid ethyl ester

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tributyltin chloride; sodium cyanoborohydride; In tert-butyl alcohol; for 1h;
DOI:10.1016/S0040-4039(00)74816-7

Reference yield:

: 135006-42-7
2-((4R,5R)-2,2,5-Trimethyl-[1,3]dioxan-4-yl)-ethanol

: 143521-70-4
{(2R,4R)-2-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-ethoxy-tetrahydro-pyran-4-yl}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1) DMSO, (COCl)2, 2) Et₃N / 1) CH₂Cl₂, -78 deg C

2: 73 percent / benzene / 8 h

3: conc. HCl / methanol / 2 h

4: 71 percent / imidazole / dimethylformamide / 12 h

5: 88 percent / NBS / CH₂Cl₂ / 5 h / -10 deg C to r.t.

6: 78 percent / Bu₃SnCl, NaCNBH₃, AIBN / 2-methyl-propan-2-ol / 1 h

With 1H-imidazole; hydrogenchloride; N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); tributyltin chloride; sodium cyanoborohydride; dimethyl sulfoxide; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4039(00)74816-7

Reference yield:

: 143521-68-0
(E)-(5R,6R)-5,7-Dihydroxy-6-methyl-hept-2-enoic acid ethyl ester

: 143521-70-4
{(2R,4R)-2-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-ethoxy-tetrahydro-pyran-4-yl}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / imidazole / dimethylformamide / 12 h

2: 88 percent / NBS / CH₂Cl₂ / 5 h / -10 deg C to r.t.

3: 78 percent / Bu₃SnCl, NaCNBH₃, AIBN / 2-methyl-propan-2-ol / 1 h

With 1H-imidazole; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tributyltin chloride; sodium cyanoborohydride; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0040-4039(00)74816-7