2-{3-Butyl-5-oxo-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5-dihydro-[1,2,4]triazol-1-yl}-3-methyl-butyric acid methyl ester

Base Information

Chemical Name:2-{3-Butyl-5-oxo-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5-dihydro-[1,2,4]triazol-1-yl}-3-methyl-butyric acid methyl ester
CAS No.:150312-71-3
Molecular Formula:C₂₆H₃₁N₇O₃
Molecular Weight:489.577
Hs Code.:

Synonyms:2-{3-Butyl-5-oxo-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5-dihydro-[1,2,4]triazol-1-yl}-3-methyl-butyric acid methyl ester

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Chemical Property of 2-{3-Butyl-5-oxo-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5-dihydro-[1,2,4]triazol-1-yl}-3-methyl-butyric acid methyl ester

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Technology Process of 2-{3-Butyl-5-oxo-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5-dihydro-[1,2,4]triazol-1-yl}-3-methyl-butyric acid methyl ester

There total 7 articles about 2-{3-Butyl-5-oxo-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5-dihydro-[1,2,4]triazol-1-yl}-3-methyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-{3-Butyl-5-oxo-4-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5-dihydro-[1,2,4]triazol-1-yl}-3-methyl-butyric acid methyl ester

: 150312-71-3
2-{3-Butyl-5-oxo-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5-dihydro-[1,2,4]triazol-1-yl}-3-methyl-butyric acid methyl ester

Guidance literature:: With acetic acid; In water; Yield given; Ambient temperature;
DOI:10.1021/jm00069a015

Reference yield:

: 69367-52-8,70332-52-4,114528-93-7,26330-51-8
methyl 2-bromo-3-methylbutanoic ester

: 150312-71-3
2-{3-Butyl-5-oxo-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5-dihydro-[1,2,4]triazol-1-yl}-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, RT, 2 h, 2.) DMF, RT, 3 h

2: glacial acetic acid / H₂O / Ambient temperature

With sodium hydride; acetic acid; In water;
DOI:10.1021/jm00069a015

Reference yield:

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 150312-71-3
2-{3-Butyl-5-oxo-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5-dihydro-[1,2,4]triazol-1-yl}-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / lithium azide / dimethylsulfoxide / 4 h / Ambient temperature

2: 1.) triphenylphosphine, 2.) H₂O / 1.) THF, RT, 2 h, 2.) THF, 23 h

3: 42 percent / ethanol / 3.5 h / 80 °C

4: 1.) NaH / 1.) DMF, RT, 2 h, 2.) DMF, RT, 3 h

5: glacial acetic acid / H₂O / Ambient temperature

With lithium azide; water; sodium hydride; acetic acid; triphenylphosphine; In ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jm00069a015