3-<4-(2-Hydroxyethyl)phenyl>-1-(4-tolylsulfonyl)indol-4-carboxamidoxim

Base Information

• Chemical Name: 3-<4-(2-Hydroxyethyl)phenyl>-1-(4-tolylsulfonyl)indol-4-carboxamidoxim
• CAS No.: 167084-24-4
• Molecular Formula: C₂₄H₂₃N₃O₄S
• Molecular Weight: 449.53
• Mol file: 167084-24-4.mol

Synonyms:3-<4-(2-Hydroxyethyl)phenyl>-1-(4-tolylsulfonyl)indol-4-carboxamidoxim

Chemical Property of 3-<4-(2-Hydroxyethyl)phenyl>-1-(4-tolylsulfonyl)indol-4-carboxamidoxim

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-<4-(2-Hydroxyethyl)phenyl>-1-(4-tolylsulfonyl)indol-4-carboxamidoxim

There total 5 articles about 3-<4-(2-Hydroxyethyl)phenyl>-1-(4-tolylsulfonyl)indol-4-carboxamidoxim which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

3-<4-(2-Hydroxyethyl)phenyl>-1-(4-tolylsulfonyl)indol-4-carbonitril (167084-23-3) → 3-<4-(2-Hydroxyethyl)phenyl>-1-(4-tolylsulfonyl)indol-4-carboxamid (167084-25-5) + 3-<4-(2-Hydroxyethyl)phenyl>-1-(4-tolylsulfonyl)indol-4-carboxamidoxim (167084-24-4)

Guidance literature:

With hydroxylamine hydrochloride; triethylamine; In ethanol; for 24h; Heating;

Reference yield:

4-cyanoindole (16136-52-0) → 3-<4-(2-Hydroxyethyl)phenyl>-1-(4-tolylsulfonyl)indol-4-carboxamidoxim (167084-24-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / KOH, I₂ / dimethylformamide / 0.25 h / Ambient temperature

2: K₂CO₃ / butan-2-one / 5 h / Heating

4: 90 percent / 10M aq. HCl / methanol / 2 h / Ambient temperature

5: 27 percent / NH₂OH*HCl, Et₃N / ethanol / 24 h / Heating

With hydrogenchloride; potassium hydroxide; hydroxylamine hydrochloride; iodine; potassium carbonate; triethylamine; In methanol; ethanol; N,N-dimethyl-formamide; butanone;

Reference yield:

3-Iodindol-4-carbonitril (167084-11-9) → 3-<4-(2-Hydroxyethyl)phenyl>-1-(4-tolylsulfonyl)indol-4-carboxamidoxim (167084-24-4)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / butan-2-one / 5 h / Heating

3: 90 percent / 10M aq. HCl / methanol / 2 h / Ambient temperature

4: 27 percent / NH₂OH*HCl, Et₃N / ethanol / 24 h / Heating

With hydrogenchloride; hydroxylamine hydrochloride; potassium carbonate; triethylamine; In methanol; ethanol; butanone;

upstream raw materials:

3-<4-(2-Hydroxyethyl)phenyl>-1-(4-tolylsulfonyl)indol-4-carbonitril

4-cyanoindole

3-Iodindol-4-carbonitril

3-Iod-1-(4-tolylsulfonyl)indol-4-carbonitril