5-(2-Fluoro-benzyl)-4-(4-methyl-piperazin-1-yl)-2-pyridin-2-yl-pyrimidine

Base Information

Chemical Name:5-(2-Fluoro-benzyl)-4-(4-methyl-piperazin-1-yl)-2-pyridin-2-yl-pyrimidine
CAS No.:1269625-85-5
Molecular Formula:C₂₁H₂₂FN₅
Molecular Weight:363.438
Hs Code.:

Synonyms:5-(2-Fluoro-benzyl)-4-(4-methyl-piperazin-1-yl)-2-pyridin-2-yl-pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(2-Fluoro-benzyl)-4-(4-methyl-piperazin-1-yl)-2-pyridin-2-yl-pyrimidine

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Technology Process of 5-(2-Fluoro-benzyl)-4-(4-methyl-piperazin-1-yl)-2-pyridin-2-yl-pyrimidine

There total 5 articles about 5-(2-Fluoro-benzyl)-4-(4-methyl-piperazin-1-yl)-2-pyridin-2-yl-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 109-01-3
1-methyl-piperazine

: 1269625-75-3
4-chloro-5-(2-fluoro-benzyl)-2-pyridin-2-yl-pyrimidine

: 1269625-85-5
5-(2-Fluoro-benzyl)-4-(4-methyl-piperazin-1-yl)-2-pyridin-2-yl-pyrimidine

Guidance literature:: With DIPEA; In methanol; ethanol;

Reference yield:

: 1643-26-1
3-(2-fluorophenyl)propionic acid

: 1269625-85-5
5-(2-Fluoro-benzyl)-4-(4-methyl-piperazin-1-yl)-2-pyridin-2-yl-pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / methanol

2: tributyl-amine; trimethylsilyl trifluoromethanesulfonate / titanium tetrachloride / water; toluene

3: sodium methylate / methanol; diethyl ether

4: trichlorophosphate / N,N-dimethyl-aniline

5: DIPEA / methanol; ethanol

With thionyl chloride; tributyl-amine; trimethylsilyl trifluoromethanesulfonate; DIPEA; sodium methylate; trichlorophosphate; titanium tetrachloride; In methanol; diethyl ether; ethanol; water; N,N-dimethyl-aniline; toluene;

Reference yield:

: 143654-59-5
methyl 3-(2-fluorophenyl)propanoate

: 1269625-85-5
5-(2-Fluoro-benzyl)-4-(4-methyl-piperazin-1-yl)-2-pyridin-2-yl-pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: tributyl-amine; trimethylsilyl trifluoromethanesulfonate / titanium tetrachloride / water; toluene

2: sodium methylate / methanol; diethyl ether

3: trichlorophosphate / N,N-dimethyl-aniline

4: DIPEA / methanol; ethanol

With tributyl-amine; trimethylsilyl trifluoromethanesulfonate; DIPEA; sodium methylate; trichlorophosphate; titanium tetrachloride; In methanol; diethyl ether; ethanol; water; N,N-dimethyl-aniline; toluene;