ethyl 2-(6-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-((2R,6S)-2,6-dimethylmorpholino)-3-fluoropyrudin-2-yl)-2-oxoacetate

Base Information

Chemical Name:ethyl 2-(6-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-((2R,6S)-2,6-dimethylmorpholino)-3-fluoropyrudin-2-yl)-2-oxoacetate
CAS No.:1223445-81-5
Molecular Formula:C₃₂H₃₈ClFN₂O₅Si
Molecular Weight:613.201
Hs Code.:

Synonyms:ethyl 2-(6-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-((2R,6S)-2,6-dimethylmorpholino)-3-fluoropyrudin-2-yl)-2-oxoacetate

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Chemical Property of ethyl 2-(6-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-((2R,6S)-2,6-dimethylmorpholino)-3-fluoropyrudin-2-yl)-2-oxoacetate

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Technology Process of ethyl 2-(6-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-((2R,6S)-2,6-dimethylmorpholino)-3-fluoropyrudin-2-yl)-2-oxoacetate

There total 1 articles about ethyl 2-(6-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-((2R,6S)-2,6-dimethylmorpholino)-3-fluoropyrudin-2-yl)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1105510-17-5
(2R,6S)-4-(2-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-fluoropyridin-3-yl)-2,6-dimethylmorpholine

: 95-92-1
oxalic acid diethyl ester

: 1223445-81-5
ethyl 2-(6-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-((2R,6S)-2,6-dimethylmorpholino)-3-fluoropyrudin-2-yl)-2-oxoacetate

Guidance literature:: (2R,6S)-4-(2-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-fluoropyridin-3-yl)-2,6-dimethylmorpholine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexanes; at -78 ℃; for 1.08333h;

oxalic acid diethyl ester; In tetrahydrofuran; hexanes; at -78 ℃; for 2.58333h;

With water; ammonium chloride; In tetrahydrofuran; hexanes; at -78 ℃;