4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-N-methyl-N-phenyl-benzenesulfonamide

Base Information

Chemical Name:4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-N-methyl-N-phenyl-benzenesulfonamide
CAS No.:1070973-28-2
Molecular Formula:C₂₁H₁₅ClF₃N₃O₃S
Molecular Weight:481.883
Hs Code.:

Synonyms:4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-N-methyl-N-phenyl-benzenesulfonamide

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Chemical Property of 4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-N-methyl-N-phenyl-benzenesulfonamide

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Technology Process of 4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-N-methyl-N-phenyl-benzenesulfonamide

There total 7 articles about 4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-N-methyl-N-phenyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070973-30-6
4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-benzenesulfonyl chloride

: 100-61-8
N-methylaniline

: 1070973-28-2
4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-N-methyl-N-phenyl-benzenesulfonamide

Guidance literature:: 4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-benzenesulfonyl chloride; N-methylaniline; With pyridine; In dichloromethane; at 20 ℃; for 16h;

With hydrogenchloride; In dichloromethane; water;

Reference yield:

: 1070892-04-4
5-bromo-2-trifluoromethylisonicotinonitrile

: 1070973-28-2
4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-N-methyl-N-phenyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 6 h / 85 °C

2.1: chlorosulfonic acid / chloroform / 16 h / 20 °C

2.2: 16 h / 60 °C

3.1: pyridine / dichloromethane / 16 h / 20 °C

With pyridine; chlorosulfonic acid; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; chloroform; water;

Reference yield:

: 1070892-03-3
5-bromo-2-trifluoromethylisonicotinamide

: 1070973-28-2
4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-N-methyl-N-phenyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 3 h / 70 °C

1.2: 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 6 h / 85 °C

3.1: chlorosulfonic acid / chloroform / 16 h / 20 °C

3.2: 16 h / 60 °C

4.1: pyridine / dichloromethane / 16 h / 20 °C

With pyridine; chlorosulfonic acid; sodium carbonate; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; chloroform; water;