(2R,3R)-N-(2-cyclopropyl-2-oxoethyl)-N-diphenylmethyl-2,3-epoxybutanamide

Base Information

Chemical Name:(2R,3R)-N-(2-cyclopropyl-2-oxoethyl)-N-diphenylmethyl-2,3-epoxybutanamide
CAS No.:691357-67-2
Molecular Formula:C₂₂H₂₃NO₃
Molecular Weight:349.43
Hs Code.:

Synonyms:(2R,3R)-N-(2-cyclopropyl-2-oxoethyl)-N-diphenylmethyl-2,3-epoxybutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-N-(2-cyclopropyl-2-oxoethyl)-N-diphenylmethyl-2,3-epoxybutanamide

Chemical Property:

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Technology Process of (2R,3R)-N-(2-cyclopropyl-2-oxoethyl)-N-diphenylmethyl-2,3-epoxybutanamide

There total 5 articles about (2R,3R)-N-(2-cyclopropyl-2-oxoethyl)-N-diphenylmethyl-2,3-epoxybutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: sodium (2R,3R)-cis-2,3-epoxybutanoate

: 691357-65-0
1-cyclopropyl-2-[(diphenylmethyl)amino]ethanone

: 691357-67-2
(2R,3R)-N-(2-cyclopropyl-2-oxoethyl)-N-diphenylmethyl-2,3-epoxybutanamide

Guidance literature:: sodium (2R,3R)-cis-2,3-epoxybutanoate; With oxalyl dichloride; In tetrahydrofuran; at -5 ℃; for 2h;

1-cyclopropyl-2-[(diphenylmethyl)amino]ethanone; With pyridine; In tetrahydrofuran; at -5 ℃; for 2h;
DOI:10.1021/jo030377y

Reference yield:

: 113318-74-4
(2R,3R)-epoxybutanoic acid chloride

: 691357-65-0
1-cyclopropyl-2-[(diphenylmethyl)amino]ethanone

: 691357-67-2
(2R,3R)-N-(2-cyclopropyl-2-oxoethyl)-N-diphenylmethyl-2,3-epoxybutanamide

Guidance literature:: With pyridine; In tetrahydrofuran; at -5 - 20 ℃; for 3h;
DOI:10.1002/ejoc.200600235

Reference yield:

: 69267-75-0
2-bromo-1-cyclopropylethan-1-one

: 691357-67-2
(2R,3R)-N-(2-cyclopropyl-2-oxoethyl)-N-diphenylmethyl-2,3-epoxybutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 98.8 percent / potassium carbonate; potassium iodide / dimethylformamide / 4 h / 90 °C

2: 3.4 g / pyridine / tetrahydrofuran / 3 h / -5 - 20 °C

With pyridine; potassium carbonate; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200600235