(R)-ethyl 4-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-4-phenylbutanoate

Base Information

• Chemical Name: (R)-ethyl 4-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-4-phenylbutanoate
• CAS No.: 1228363-42-5
• Molecular Formula: C₁₈H₁₈O₆
• Molecular Weight: 330.337
• Mol file: 1228363-42-5.mol

Synonyms:(R)-ethyl 4-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-4-phenylbutanoate

Chemical Property of (R)-ethyl 4-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-4-phenylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-ethyl 4-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-4-phenylbutanoate

There total 2 articles about (R)-ethyl 4-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-4-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-hydroxy-6-methyl-2-pyron (675-10-5) + ethyl 4-phenyl-2-oxobut-3-enoate (55629-96-4,55674-14-1,17451-20-6) → (R)-ethyl 4-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-4-phenylbutanoate (1228363-42-5)

Guidance literature:

With 3-(((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-inylquinuclidin-2-yl)methyl)amino)-4-(((R)-1-phenylethyl)amino)cyclobut-3-ene-1,2-dione; In 1,2-dichloro-ethane; at 20 ℃; for 12h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/chem.201000094

Reference yield:

4-hydroxy-6-methyl-2-pyron (675-10-5) + ethyl 4-phenyl-2-oxobut-3-enoate (55629-96-4,55674-14-1,17451-20-6) → (R)-ethyl 4-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-4-phenylbutanoate (1228363-42-5) + ethyl 4-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-4-phenylbutanoate

Guidance literature:

With C₄₁H₄₂N₂O₃; diethylzinc; In hexane; toluene; at 0 - 20 ℃; for 15h; Overall yield = 94 percent; Overall yield = 38.7 mg; enantioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.9b02046

upstream raw materials:

4-hydroxy-6-methyl-2-pyron

ethyl 4-phenyl-2-oxobut-3-enoate