5-(4-(1H-pyrazol-1-yl)phenylamino)-7-(cyclopropylamino)-6-methylpyrazolo[1,5-a]pyrimidine-3-carbaldehyde

Base Information

Chemical Name:5-(4-(1H-pyrazol-1-yl)phenylamino)-7-(cyclopropylamino)-6-methylpyrazolo[1,5-a]pyrimidine-3-carbaldehyde
CAS No.:1273190-08-1
Molecular Formula:C₂₀H₁₉N₇O
Molecular Weight:373.417
Hs Code.:

Synonyms:5-(4-(1H-pyrazol-1-yl)phenylamino)-7-(cyclopropylamino)-6-methylpyrazolo[1,5-a]pyrimidine-3-carbaldehyde

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Chemical Property of 5-(4-(1H-pyrazol-1-yl)phenylamino)-7-(cyclopropylamino)-6-methylpyrazolo[1,5-a]pyrimidine-3-carbaldehyde

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Technology Process of 5-(4-(1H-pyrazol-1-yl)phenylamino)-7-(cyclopropylamino)-6-methylpyrazolo[1,5-a]pyrimidine-3-carbaldehyde

There total 6 articles about 5-(4-(1H-pyrazol-1-yl)phenylamino)-7-(cyclopropylamino)-6-methylpyrazolo[1,5-a]pyrimidine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₇N₇O₃

: 1273190-08-1
5-(4-(1H-pyrazol-1-yl)phenylamino)-7-(cyclopropylamino)-6-methylpyrazolo[1,5-a]pyrimidine-3-carbaldehyde

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1273190-02-5
5-chloro-N-cyclopropyl-6-methylpyrazolo[1,5-a]pyrimidin-7-amine

: 1273190-08-1
5-(4-(1H-pyrazol-1-yl)phenylamino)-7-(cyclopropylamino)-6-methylpyrazolo[1,5-a]pyrimidine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 10 h / 20 °C

2: triethylamine / dmap / dichloromethane / 10 h / 20 °C

3: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 1 h / 110 °C / Microwave irradiation

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With caesium carbonate; triethylamine; trifluoroacetic acid; trichlorophosphate; dmap; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; dichloromethane;

Reference yield:

: 61098-38-2
5,7-dichloro-6-methyl-pyrazolo[1,5-a]pyrimidine

: 1273190-08-1
5-(4-(1H-pyrazol-1-yl)phenylamino)-7-(cyclopropylamino)-6-methylpyrazolo[1,5-a]pyrimidine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / acetonitrile / 9 h / 20 - 85 °C

2: trichlorophosphate / 10 h / 20 °C

3: triethylamine / dmap / dichloromethane / 10 h / 20 °C

4: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 1 h / 110 °C / Microwave irradiation

5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With caesium carbonate; triethylamine; trifluoroacetic acid; trichlorophosphate; dmap; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; dichloromethane; acetonitrile;