Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(3-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-

Base Information

• Chemical Name: Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(3-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-
• CAS No.: 123437-49-0
• Molecular Formula: C₂₆H₂₁N₃O₃
• Molecular Weight: 423.471
• Mol file: 123437-49-0.mol

Synonyms:Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(3-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-

Chemical Property of Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(3-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-

Chemical Property:

• PSA: 90.62000
• LogP: 4.28240

Purity/Quality:

Safty Information:

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• Hazard Codes: 

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Technology Process of Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(3-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-

There total 7 articles about Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(3-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-benzyl-2-(3-hydroxybenzyl)-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3-yl acetate → 8-benzyl-2-(4-hydroxybenzyl)-6-(3-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one (123437-49-0)

Guidance literature:

With hydrogenchloride; In ethanol; water; dimethyl sulfoxide; at 50 ℃;

DOI:10.1039/C9OB00459A

Reference yield:

ethyl 2-(3-benzyl-5-(3-(benzyloxy)phenyl)pyrazin-2-ylamino)-3-(4-(benzyloxy)phenyl)propanoate → 8-benzyl-2-(4-hydroxybenzyl)-6-(3-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one (123437-49-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide / tetrahydrofuran / 20 °C / Inert atmosphere

2: tetrahydrofuran / 20 °C / Inert atmosphere

3: acetic acid; palladium 10% on activated carbon; hydrogen / ethyl acetate; ethanol

4: hydrogenchloride / water; ethanol; dimethyl sulfoxide / 50 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; acetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; ethyl acetate;

DOI:10.1039/C9OB00459A

Reference yield:

8-benzyl-2-(4-(benzyloxy)benzyl)-6-(3-(benzyloxy)phenyl)imidazo[1,2-a]pyrazin-3-yl acetate → 8-benzyl-2-(4-hydroxybenzyl)-6-(3-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one (123437-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; palladium 10% on activated carbon; hydrogen / ethyl acetate; ethanol

2: hydrogenchloride / water; ethanol; dimethyl sulfoxide / 50 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; acetic acid; In ethanol; water; dimethyl sulfoxide; ethyl acetate;

DOI:10.1039/C9OB00459A

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