(2S,3S)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutyryl-L-prolyl-methyl ester

Base Information

Chemical Name:(2S,3S)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutyryl-L-prolyl-methyl ester
CAS No.:863640-20-4
Molecular Formula:C₂₄H₂₈N₂O₆
Molecular Weight:440.496
Hs Code.:

Synonyms:(2S,3S)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutyryl-L-prolyl-methyl ester

Suppliers and Price of (2S,3S)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutyryl-L-prolyl-methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutyryl-L-prolyl-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutyryl-L-prolyl-methyl ester

There total 6 articles about (2S,3S)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutyryl-L-prolyl-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 62023-59-0,76498-22-1
(2S,3S)-3-benzyloxycarbonylamino-2-hydroxy-4-phenylbutanoic acid

: 863640-20-4
(2S,3S)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutyryl-L-prolyl-methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 18h;
DOI:10.1021/ja00153a008

Reference yield: 63.0%

: 2133-40-6
L-proline methyl ester monohydrochloride

: 62023-59-0,76498-22-1
(2S,3S)-3-benzyloxycarbonylamino-2-hydroxy-4-phenylbutanoic acid

: 863640-20-4
(2S,3S)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutyryl-L-prolyl-methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 4 - 20 ℃;
DOI:10.1016/j.bmc.2005.05.040

Reference yield:

: 121253-57-4
β-<<(phenylmethoxy)carbonyl>amino>-α-oxobenzenebutanoic acid ethyl ester

: 863640-20-4
(2S,3S)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutyryl-L-prolyl-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄ / methanol / 0.33 h / 0 °C

2: 92 percent / 0.25 N LiOH / methanol; H₂O / 0.5 h / Ambient temperature

3: 63 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide HCl, 1-hydroxybenzotriazole, diisopropylethylamine / dimethylformamide / 18 h

With lithium hydroxide; sodium tetrahydroborate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ja00153a008