1-benzyl-3-(1H-indol-3-yl)-4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-3-yl]-pyrrole-2,5-dione

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Chemical Name:1-benzyl-3-(1H-indol-3-yl)-4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-3-yl]-pyrrole-2,5-dione
CAS No.:797055-98-2
Molecular Formula:C₃₃H₃₃N₃O₃Si
Molecular Weight:547.729
Hs Code.:

Synonyms:1-benzyl-3-(1H-indol-3-yl)-4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-3-yl]-pyrrole-2,5-dione

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Chemical Property of 1-benzyl-3-(1H-indol-3-yl)-4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-3-yl]-pyrrole-2,5-dione

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Technology Process of 1-benzyl-3-(1H-indol-3-yl)-4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-3-yl]-pyrrole-2,5-dione

There total 5 articles about 1-benzyl-3-(1H-indol-3-yl)-4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-3-yl]-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 120-72-9
indole

: 797056-00-9
1-benzyl-3-chloro-4-bis-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-3-yl]-pyrrole-2,5-dione

: 797055-98-2
1-benzyl-3-(1H-indol-3-yl)-4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-3-yl]-pyrrole-2,5-dione

Guidance literature:: indole; With ethylmagnesium bromide; In diethyl ether; toluene; at 0 ℃; for 1h;

1-benzyl-3-chloro-4-bis-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-3-yl]-pyrrole-2,5-dione; In diethyl ether; toluene; at 23 ℃; for 16h;
DOI:10.1039/b405010j

Reference yield: 52.0%

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 91026-01-6
2,3-bis(1H-indol-3-yl)-N-benzylmaleimide

: 797055-98-2
1-benzyl-3-(1H-indol-3-yl)-4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-3-yl]-pyrrole-2,5-dione

: 1-benzyl-3,4-bis-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-3-yl]-pyrrole-2,5-dione

Guidance literature:: 2,3-bis(1H-indol-3-yl)-N-benzylmaleimide; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.333333h;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; at 23 ℃; for 6h;
DOI:10.1039/b405010j

Reference yield:

: 16114-24-2
1-benzyl-3,4-dichloro-pyrrole-2,5-dione

: 797055-98-2
1-benzyl-3-(1H-indol-3-yl)-4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-3-yl]-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: EtMgBr / tetrahydrofuran; diethyl ether; toluene / Heating

1.2: 67 percent / tetrahydrofuran; diethyl ether; toluene / Heating

2.1: NaH / tetrahydrofuran / 0.33 h / 0 °C

2.2: 52 percent / tetrahydrofuran / 6 h / 23 °C

With ethylmagnesium bromide; sodium hydride; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1039/b405010j