1-[(2R,3R,4R,5R)-4-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-dihydro-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2R,3R,4R,5R)-4-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-dihydro-pyrimidine-2,4-dione
CAS No.:162825-86-7
Molecular Formula:C₃₄H₃₈N₂O₈
Molecular Weight:602.684
Hs Code.:

1-[(2R,3R,4R,5R)-4-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-dihydro-pyrimidine-2,4-dione

Synonyms:1-[(2R,3R,4R,5R)-4-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-dihydro-pyrimidine-2,4-dione

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Chemical Property of 1-[(2R,3R,4R,5R)-4-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-dihydro-pyrimidine-2,4-dione

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Technology Process of 1-[(2R,3R,4R,5R)-4-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-dihydro-pyrimidine-2,4-dione

There total 4 articles about 1-[(2R,3R,4R,5R)-4-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-dihydro-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1-[(2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-dihydro-pyrimidine-2,4-dione

: 14470-28-1
mono-4-methoxytrityl chloride

: 162825-86-7
1-[(2R,3R,4R,5R)-4-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-dihydro-pyrimidine-2,4-dione

Guidance literature:: With pyridine; for 72h; Ambient temperature;
DOI:10.1080/15257779508014659

Reference yield:

: 5627-05-4
5,6-dihydrouridine

: 162825-86-7
1-[(2R,3R,4R,5R)-4-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-dihydro-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / pyridine / 3 h / Ambient temperature

2: p-TsOH / 4 h / pH 4

3: triethylammonium fluoride / tetrahydrofuran / 24 h / Ambient temperature

4: 90 percent / pyridine / 72 h / Ambient temperature

With pyridine; toluene-4-sulfonic acid; triethylamine hydrofluoride; In tetrahydrofuran;
DOI:10.1080/15257779508014659

Reference yield:

: 162825-83-4
5,6-dihydro-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 162825-86-7
1-[(2R,3R,4R,5R)-4-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-dihydro-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: p-TsOH / 4 h / pH 4

2: triethylammonium fluoride / tetrahydrofuran / 24 h / Ambient temperature

3: 90 percent / pyridine / 72 h / Ambient temperature

With pyridine; toluene-4-sulfonic acid; triethylamine hydrofluoride; In tetrahydrofuran;
DOI:10.1080/15257779508014659