N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(ethyl(methyl)amino)-N-isobutylbenzo[d]oxazole-6-carboxamide

Base Information

Chemical Name:N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(ethyl(methyl)amino)-N-isobutylbenzo[d]oxazole-6-carboxamide
CAS No.:1160490-17-4
Molecular Formula:C₂₅H₃₄N₄O₃
Molecular Weight:438.57
Hs Code.:

Synonyms:N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(ethyl(methyl)amino)-N-isobutylbenzo[d]oxazole-6-carboxamide

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Chemical Property of N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(ethyl(methyl)amino)-N-isobutylbenzo[d]oxazole-6-carboxamide

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Technology Process of N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(ethyl(methyl)amino)-N-isobutylbenzo[d]oxazole-6-carboxamide

There total 8 articles about N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(ethyl(methyl)amino)-N-isobutylbenzo[d]oxazole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1160490-16-3
N-((2R,3S)-3-(dibenzylamino)-2-hydroxy-4-phenylbutyl)-2-(ethyl(methyl)amino)-N-isobutyl-benzo[d]oxazole-6-carboxamide

: 1160490-17-4
N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(ethyl(methyl)amino)-N-isobutylbenzo[d]oxazole-6-carboxamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃;

Reference yield:

: C₃₀H₄₂N₄O₅

: 1160490-17-4
N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(ethyl(methyl)amino)-N-isobutylbenzo[d]oxazole-6-carboxamide

Guidance literature:: With chloro-trimethyl-silane; sodium iodide; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2012.06.022

Reference yield:

: 72752-81-9
methyl 2-mercapto-1,3-benzoxazole-6-carboxylate

: 1160490-17-4
N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(ethyl(methyl)amino)-N-isobutylbenzo[d]oxazole-6-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / ethyl acetate / 12 h / 20 °C

2: tetrahydrofuran / 70 °C

3: water; lithium hydroxide / tetrahydrofuran / 70 °C

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 20 °C

5: chloro-trimethyl-silane; sodium iodide / acetonitrile / 2 h / 20 °C

With chloro-trimethyl-silane; water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; sodium iodide; lithium hydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2012.06.022