(E)-2-Acetoxy-4-{4-[2-(N-benzyloxycarbonyl-N-methylamino)ethoxy]phenyl}-3,4-diphenyl-3-butene

Base Information

Chemical Name:(E)-2-Acetoxy-4-{4-[2-(N-benzyloxycarbonyl-N-methylamino)ethoxy]phenyl}-3,4-diphenyl-3-butene
CAS No.:288617-59-4
Molecular Formula:C₃₅H₃₅NO₅
Molecular Weight:549.667
Hs Code.:

Synonyms:(E)-2-Acetoxy-4-{4-[2-(N-benzyloxycarbonyl-N-methylamino)ethoxy]phenyl}-3,4-diphenyl-3-butene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-Acetoxy-4-{4-[2-(N-benzyloxycarbonyl-N-methylamino)ethoxy]phenyl}-3,4-diphenyl-3-butene

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Technology Process of (E)-2-Acetoxy-4-{4-[2-(N-benzyloxycarbonyl-N-methylamino)ethoxy]phenyl}-3,4-diphenyl-3-butene

There total 5 articles about (E)-2-Acetoxy-4-{4-[2-(N-benzyloxycarbonyl-N-methylamino)ethoxy]phenyl}-3,4-diphenyl-3-butene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 108-24-7
acetic anhydride

: 288617-58-3
(E)-4-{4-[2-(N-Benzyloxycarbonyl-N-methylamino)ethoxy]phenyl}-3,4-diphenyl-3-buten-2-ol

: 288617-59-4
(E)-2-Acetoxy-4-{4-[2-(N-benzyloxycarbonyl-N-methylamino)ethoxy]phenyl}-3,4-diphenyl-3-butene

Guidance literature:: With pyridine; at 20 ℃; for 15h;
DOI:10.1021/tx000074o

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 288617-59-4
(E)-2-Acetoxy-4-{4-[2-(N-benzyloxycarbonyl-N-methylamino)ethoxy]phenyl}-3,4-diphenyl-3-butene

Guidance literature:: Multi-step reaction with 2 steps

1: 95 mg / Et₃N / methanol / 1 h / 0 °C

2: 73 percent / pyridine / 15 h / 20 °C

With pyridine; triethylamine; In methanol;
DOI:10.1021/tx000074o

Reference yield:

: 97151-02-5
(E)-(+/-)-alpha-Hydroxytamoxifen

: 288617-59-4
(E)-2-Acetoxy-4-{4-[2-(N-benzyloxycarbonyl-N-methylamino)ethoxy]phenyl}-3,4-diphenyl-3-butene

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / benzene / 1 h / Heating

2: N₂H₄*H₂O; KOH / ethane-1,2-diol / 2 h / 140 °C

3: 95 mg / Et₃N / methanol / 1 h / 0 °C

4: 73 percent / pyridine / 15 h / 20 °C

With pyridine; potassium hydroxide; hydrazine hydrate; triethylamine; In methanol; ethylene glycol; benzene;
DOI:10.1021/tx000074o