2-[2-(4-Bromo-phenyl)-5-phenyl-2H-pyrazol-3-yl]-3-(4-chloro-phenyl)-3H-quinazolin-4-one

Base Information

Chemical Name:2-[2-(4-Bromo-phenyl)-5-phenyl-2H-pyrazol-3-yl]-3-(4-chloro-phenyl)-3H-quinazolin-4-one
CAS No.:128458-12-8
Molecular Formula:C₂₉H₁₈BrClN₄O
Molecular Weight:553.845
Hs Code.:

Synonyms:2-[2-(4-Bromo-phenyl)-5-phenyl-2H-pyrazol-3-yl]-3-(4-chloro-phenyl)-3H-quinazolin-4-one

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Chemical Property of 2-[2-(4-Bromo-phenyl)-5-phenyl-2H-pyrazol-3-yl]-3-(4-chloro-phenyl)-3H-quinazolin-4-one

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Technology Process of 2-[2-(4-Bromo-phenyl)-5-phenyl-2H-pyrazol-3-yl]-3-(4-chloro-phenyl)-3H-quinazolin-4-one

There total 3 articles about 2-[2-(4-Bromo-phenyl)-5-phenyl-2H-pyrazol-3-yl]-3-(4-chloro-phenyl)-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 622-88-8,41931-18-4
4-bromophenylhydrazine hydrochloride

: 128457-94-3
3-(4-Chloro-phenyl)-2-((E)-3-oxo-3-phenyl-propenyl)-3H-quinazolin-4-one

: 128458-12-8
2-[2-(4-Bromo-phenyl)-5-phenyl-2H-pyrazol-3-yl]-3-(4-chloro-phenyl)-3H-quinazolin-4-one

Guidance literature:: With sodium acetate; In ethanol; for 6h; Heating; other solvent: glacial acetic acid;
DOI:10.1002/ardp.19903230511

Reference yield:

: 1074-12-0
phenylglyoxal hydrate

: 128458-12-8
2-[2-(4-Bromo-phenyl)-5-phenyl-2H-pyrazol-3-yl]-3-(4-chloro-phenyl)-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / acetic anhydride / 0.25 h / Heating

2: 76 percent / anhydrous sodium acetate / ethanol / 6 h / Heating; other solvent: glacial acetic acid

With sodium acetate; In ethanol; acetic anhydride;
DOI:10.1002/ardp.19903230511

Reference yield:

: 1788-93-8
3-(4-chlorophenyl)-2-methyl-3H-quinazolin-4-one

: 128458-12-8
2-[2-(4-Bromo-phenyl)-5-phenyl-2H-pyrazol-3-yl]-3-(4-chloro-phenyl)-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / acetic anhydride / 0.25 h / Heating

2: 76 percent / anhydrous sodium acetate / ethanol / 6 h / Heating; other solvent: glacial acetic acid

With sodium acetate; In ethanol; acetic anhydride;
DOI:10.1002/ardp.19903230511