1-[4-(4-{2-[(3-methylphenyl)amino]-1,3-thiazol-4-yl}-3-pyridinyl)phenyl]ethanone

Base Information

Chemical Name:1-[4-(4-{2-[(3-methylphenyl)amino]-1,3-thiazol-4-yl}-3-pyridinyl)phenyl]ethanone
CAS No.:1202801-23-7
Molecular Formula:C₂₃H₁₉N₃OS
Molecular Weight:385.489
Hs Code.:

Synonyms:1-[4-(4-{2-[(3-methylphenyl)amino]-1,3-thiazol-4-yl}-3-pyridinyl)phenyl]ethanone

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Chemical Property of 1-[4-(4-{2-[(3-methylphenyl)amino]-1,3-thiazol-4-yl}-3-pyridinyl)phenyl]ethanone

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Technology Process of 1-[4-(4-{2-[(3-methylphenyl)amino]-1,3-thiazol-4-yl}-3-pyridinyl)phenyl]ethanone

There total 3 articles about 1-[4-(4-{2-[(3-methylphenyl)amino]-1,3-thiazol-4-yl}-3-pyridinyl)phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1313590-81-6
4-(3-iodo-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine

: 149104-90-5
4-acetylphenylboronic acid

: 1202801-23-7
1-[4-(4-{2-[(3-methylphenyl)amino]-1,3-thiazol-4-yl}-3-pyridinyl)phenyl]ethanone

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide; toluene; at 90 ℃; for 16h;
DOI:10.1016/j.bmc.2011.04.042

Reference yield: 22.0%

: 1187669-53-9
4-(3-bromo-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine

: 149104-90-5
4-acetylphenylboronic acid

: 1202801-23-7
1-[4-(4-{2-[(3-methylphenyl)amino]-1,3-thiazol-4-yl}-3-pyridinyl)phenyl]ethanone

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide; toluene; at 90 ℃; Inert atmosphere;
DOI:10.1021/jm901457w

Reference yield:

: 1187669-53-9
4-(3-bromo-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine

: 1202801-23-7
1-[4-(4-{2-[(3-methylphenyl)amino]-1,3-thiazol-4-yl}-3-pyridinyl)phenyl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; N,N-dimethylethylenediamine; sodium iodide / 1,4-dioxane / 40 h / 110 °C / Sealed tube

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; water; N,N-dimethyl-formamide; toluene / 16 h / 90 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; potassium carbonate; N,N-dimethylethylenediamine; sodium iodide; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2011.04.042