2,6-dichloro-1-(5,6-dihydroxy-4-methoxymethoxy-3-methoxymethoxymethyl-cyclohex-2-enyl)-5-hydroxy-8-methyl-1H-9-oxa-1-aza-cyclopenta[b]naphthalen-4-one

Base Information

Chemical Name:2,6-dichloro-1-(5,6-dihydroxy-4-methoxymethoxy-3-methoxymethoxymethyl-cyclohex-2-enyl)-5-hydroxy-8-methyl-1H-9-oxa-1-aza-cyclopenta[b]naphthalen-4-one
CAS No.:261967-51-5
Molecular Formula:C₂₃H₂₅Cl₂NO₉
Molecular Weight:530.359
Hs Code.:

2,6-dichloro-1-(5,6-dihydroxy-4-methoxymethoxy-3-methoxymethoxymethyl-cyclohex-2-enyl)-5-hydroxy-8-methyl-1<i>H</i>-9-oxa-1-aza-cyclopenta[<i>b</i>]naphthalen-4-one

Synonyms:2,6-dichloro-1-(5,6-dihydroxy-4-methoxymethoxy-3-methoxymethoxymethyl-cyclohex-2-enyl)-5-hydroxy-8-methyl-1H-9-oxa-1-aza-cyclopenta[b]naphthalen-4-one

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Chemical Property of 2,6-dichloro-1-(5,6-dihydroxy-4-methoxymethoxy-3-methoxymethoxymethyl-cyclohex-2-enyl)-5-hydroxy-8-methyl-1H-9-oxa-1-aza-cyclopenta[b]naphthalen-4-one

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Technology Process of 2,6-dichloro-1-(5,6-dihydroxy-4-methoxymethoxy-3-methoxymethoxymethyl-cyclohex-2-enyl)-5-hydroxy-8-methyl-1H-9-oxa-1-aza-cyclopenta[b]naphthalen-4-one

There total 4 articles about 2,6-dichloro-1-(5,6-dihydroxy-4-methoxymethoxy-3-methoxymethoxymethyl-cyclohex-2-enyl)-5-hydroxy-8-methyl-1H-9-oxa-1-aza-cyclopenta[b]naphthalen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 205245-61-0
2,6-dichloro-5-hydroxy-8-methyl-[1]benzopyrano[2,3-b]pyrrol-4(1H)-one

: 261967-50-4
(1R,2S,3S,6R)-6-Methoxymethoxy-5-methoxymethoxymethyl-cyclohex-4-ene-1,2,3-triol

: 261967-51-5
2,6-dichloro-1-(5,6-dihydroxy-4-methoxymethoxy-3-methoxymethoxymethyl-cyclohex-2-enyl)-5-hydroxy-8-methyl-1H-9-oxa-1-aza-cyclopenta[b]naphthalen-4-one

Guidance literature:: With cyanomethylenetributyl-phosphorane; In tetrahydrofuran; at 40 ℃; for 12h;
DOI:10.7164/antibiotics.53.88

Reference yield:

: 261967-48-0
(4S,5S,6R)-4,5,6-Tris-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-cyclohex-2-enone

: 261967-51-5
2,6-dichloro-1-(5,6-dihydroxy-4-methoxymethoxy-3-methoxymethoxymethyl-cyclohex-2-enyl)-5-hydroxy-8-methyl-1H-9-oxa-1-aza-cyclopenta[b]naphthalen-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / NaBH₄; CeCl₃*7H₂O / methanol; CH₂Cl₂ / 3.5 h / -78 °C

2: 92 percent / n-Bu₄NI; DIPEA / CH₂Cl₂ / 24 h / 50 °C

3: 95 percent / TBAF / tetrahydrofuran / 4 h / 20 °C

4: 51 percent / n-Bu₃P=CHCN / tetrahydrofuran / 12 h / 40 °C

With sodium tetrahydroborate; cerium(III) chloride; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; cyanomethylenetributyl-phosphorane; In tetrahydrofuran; methanol; dichloromethane; 1: Reduction / 2: Alkylation / 3: desilylation / 4: Substitution;
DOI:10.7164/antibiotics.53.88

Reference yield:

: 261967-49-1
(1R,4S,5S,6S)-4,5,6-Tris-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-cyclohex-2-enol

: 261967-51-5
2,6-dichloro-1-(5,6-dihydroxy-4-methoxymethoxy-3-methoxymethoxymethyl-cyclohex-2-enyl)-5-hydroxy-8-methyl-1H-9-oxa-1-aza-cyclopenta[b]naphthalen-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / n-Bu₄NI; DIPEA / CH₂Cl₂ / 24 h / 50 °C

2: 95 percent / TBAF / tetrahydrofuran / 4 h / 20 °C

3: 51 percent / n-Bu₃P=CHCN / tetrahydrofuran / 12 h / 40 °C

With tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; cyanomethylenetributyl-phosphorane; In tetrahydrofuran; dichloromethane; 1: Alkylation / 2: desilylation / 3: Substitution;
DOI:10.7164/antibiotics.53.88