(E)-2-Amino-5-(2,4-difluoro-phenyl)-5-(4-isopropyl-phenyl)-pent-4-enoic acid methyl ester

Base Information

• Chemical Name: (E)-2-Amino-5-(2,4-difluoro-phenyl)-5-(4-isopropyl-phenyl)-pent-4-enoic acid methyl ester
• CAS No.: 288101-32-6
• Molecular Formula: C₂₁H₂₃F₂NO₂
• Molecular Weight: 359.416
• Mol file: 288101-32-6.mol

Synonyms:(E)-2-Amino-5-(2,4-difluoro-phenyl)-5-(4-isopropyl-phenyl)-pent-4-enoic acid methyl ester

Chemical Property of (E)-2-Amino-5-(2,4-difluoro-phenyl)-5-(4-isopropyl-phenyl)-pent-4-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-Amino-5-(2,4-difluoro-phenyl)-5-(4-isopropyl-phenyl)-pent-4-enoic acid methyl ester

There total 13 articles about (E)-2-Amino-5-(2,4-difluoro-phenyl)-5-(4-isopropyl-phenyl)-pent-4-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-2-(Benzhydrylidene-amino)-5-(2,4-difluoro-phenyl)-5-(4-isopropyl-phenyl)-pent-4-enoic acid methyl ester (288101-16-6) → (E)-2-Amino-5-(2,4-difluoro-phenyl)-5-(4-isopropyl-phenyl)-pent-4-enoic acid methyl ester (288101-32-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; water; at 20 ℃;

DOI:10.1016/S0040-4039(01)00353-7

Reference yield:

(4-isopropylphenyl)boronic acid (16152-51-5) → (E)-2-Amino-5-(2,4-difluoro-phenyl)-5-(4-isopropyl-phenyl)-pent-4-enoic acid methyl ester (288101-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Pd(PPh₃)4; Na₂CO₃ / 1,2-dimethoxy-ethane / 110 °C

2: aq. TFA / CH₂Cl₂ / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; trifluoroacetic acid; In 1,2-dimethoxyethane; dichloromethane; 1: Suzuki coupling;

DOI:10.1016/S0960-894X(01)00253-0

Reference yield:

(Z)-3-(2,4-Difluoro-phenyl)-3-iodo-prop-2-en-1-ol (288101-02-0) → (E)-2-Amino-5-(2,4-difluoro-phenyl)-5-(4-isopropyl-phenyl)-pent-4-enoic acid methyl ester (288101-32-6)

Guidance literature:

Multi-step reaction with 4 steps

1: PBr₃ / CH₂Cl₂ / 0 °C

2: LDA / diethyl ether / 0 °C

3: Pd(PPh₃)4; Na₂CO₃ / 1,2-dimethoxy-ethane / 110 °C

4: aq. TFA / CH₂Cl₂ / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus tribromide; sodium carbonate; trifluoroacetic acid; lithium diisopropyl amide; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; 3: Suzuki coupling;

DOI:10.1016/S0960-894X(01)00253-0

upstream raw materials:

(E)-2-(Benzhydrylidene-amino)-5-(2,4-difluoro-phenyl)-5-(4-isopropyl-phenyl)-pent-4-enoic acid methyl ester

(4-isopropylphenyl)boronic acid

3-(4-isopropyl-phenyl)-prop-2-yn-1-ol

1-(3-bromo-prop-1-ynyl)-4-isopropyl-benzene