(3S,4S)-3,4-Bis(diphenylphosphino)pyrrolidine

Base Information

• Chemical Name: (3S,4S)-3,4-Bis(diphenylphosphino)pyrrolidine
• CAS No.: 145693-67-0
• Molecular Formula: C₂₈H₂₇NP₂
• Molecular Weight: 439.477
• European Community (EC) Number: 630-832-5
• Nikkaji Number: J1.154.350B
• Wikidata: Q76423154
• Mol file: 145693-67-0.mol

Synonyms:145693-67-0;(3S,4S)-3,4-Bis(diphenylphosphino)pyrrolidine;(3S,4S)-(-)-BIS(DIPHENYLPHOSPHINO)PYRROLIDINE;[(3S,4S)-4-diphenylphosphanylpyrrolidin-3-yl]-diphenylphosphane;SCHEMBL8782008;(3R,4R)-Bis(diphenylphosphino) pyrrolidine

Chemical Property of (3S,4S)-3,4-Bis(diphenylphosphino)pyrrolidine

Chemical Property:

• Boiling Point: 564.5±50.0 °C(Predicted)
• PKA: 9.32±0.10(Predicted)
• PSA: 39.21000
• LogP: 4.92140
• XLogP3: 5.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 6
• Exact Mass: 439.16187386
• Heavy Atom Count: 31
• Complexity: 433

Purity/Quality:

(3S,4S)-(-)-BIS(DIPHENYLPHOSPHINO)PYRROLIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C(CN1)P(C2=CC=CC=C2)C3=CC=CC=C3)P(C4=CC=CC=C4)C5=CC=CC=C5
• Isomeric SMILES: C1[C@@H]([C@H](CN1)P(C2=CC=CC=C2)C3=CC=CC=C3)P(C4=CC=CC=C4)C5=CC=CC=C5

Technology Process of (3S,4S)-3,4-Bis(diphenylphosphino)pyrrolidine

There total 2 articles about (3S,4S)-3,4-Bis(diphenylphosphino)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S,4S)-3,4-bis(methylsulfonyloxy)pyrrolidinium-acetat (104351-42-0) + sodium diphenylphosphide (4376-01-6) → (3R,4R)-3,4-bis(diphenylphosphanyl)pyrrolidine (99135-90-7,145693-67-0)

Guidance literature:

In N,N-dimethyl-formamide; at -15 ℃; for 24h; Yield given;

Reference yield:

(3R,4R)-3,4-Bis(methylsulfonyloxy)pyrrolidinium-acetat + sodium diphenylphosphide (4376-01-6) → (S,S)-Pyrphos (145693-67-0)

Guidance literature:

In N,N-dimethyl-formamide; at -15 ℃;

Reference yield:

(3R,4R)-3,4-bis(diphenylphosphanyl)pyrrolidine (99135-90-7,145693-67-0) + 4-<<3-(Triethoxysilyl)propyl>carbamoyl>benzoesaeure-phenylester (104351-47-5) → 4-<(3R,4R)-3,4-Bis(diphenylphosphino)pyrrolidinocarbonyl>-N-<3-(triethoxysilyl)propyl>benzamid (104373-42-4)

Guidance literature:

at 130 ℃; for 6.5h; Yield given;

upstream raw materials:

(3S,4S)-3,4-bis(methylsulfonyloxy)pyrrolidinium-acetat

sodium diphenylphosphide

Downstream raw materials:

δ-<(3R,4R)-3,4-Bis(diphenylphophino)pyrrolidino>-δ-oxopentansaeure

4-<(3R,4R)-3,4-Bis(diphenylphosphino)pyrrolidinocarbonyl>-N-<3-(triethoxysilyl)propyl>benzamid

-1-(tert-Butoxycarbonyl)-3,4-bis-(methylphenylphosphino)pyrrolidin

(PS,3R,4R,P'S)-1-(tert-Butoxycarbonyl)-3,4-bis-(methylphenylphosphino)pyrrolidin