(4R,5R,8S,9S,10R,13S,14S,17S)-4-(4-Methoxy-benzyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-5,17-diol

Base Information

Chemical Name:(4R,5R,8S,9S,10R,13S,14S,17S)-4-(4-Methoxy-benzyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-5,17-diol
CAS No.:634152-27-5
Molecular Formula:C₂₇H₄₀O₃
Molecular Weight:412.613
Hs Code.:

Synonyms:(4R,5R,8S,9S,10R,13S,14S,17S)-4-(4-Methoxy-benzyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-5,17-diol

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Chemical Property of (4R,5R,8S,9S,10R,13S,14S,17S)-4-(4-Methoxy-benzyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-5,17-diol

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Technology Process of (4R,5R,8S,9S,10R,13S,14S,17S)-4-(4-Methoxy-benzyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-5,17-diol

There total 1 articles about (4R,5R,8S,9S,10R,13S,14S,17S)-4-(4-Methoxy-benzyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-5,17-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 824-94-2
p-methoxybenzyl chloride

: 168254-08-8
4α,5α-epoxyandrostan-17β-yl acetate

: 634152-27-5
(4R,5R,8S,9S,10R,13S,14S,17S)-4-(4-Methoxy-benzyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-5,17-diol

Guidance literature:: p-methoxybenzyl chloride; With magnesium; In tetrahydrofuran;

4α,5α-epoxyandrostan-17β-yl acetate; In tetrahydrofuran; for 4h; Heating;
DOI:10.1016/S0039-128X(03)00085-0

Reference yield: 76.0%

: 634152-27-5
(4R,5R,8S,9S,10R,13S,14S,17S)-4-(4-Methoxy-benzyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-5,17-diol

: 634152-32-2
(4R,5R,8R,9S,10R,13S,14S)-5-Hydroxy-4-(4-methoxy-benzyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one

Guidance literature:: With jones reagent; In acetone; at 0 ℃;
DOI:10.1016/S0039-128X(03)00085-0

Reference yield:

: 634152-27-5
(4R,5R,8S,9S,10R,13S,14S,17S)-4-(4-Methoxy-benzyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-5,17-diol

: (4R,8R,9S,10R,13S,14S)-4-(4-Methoxy-benzyl)-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-17-one

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / Jones reagent / acetone / 0 °C

2: 99 percent / SOCl₂; pyridine / 0.25 h / 0 °C

With pyridine; thionyl chloride; jones reagent; In acetone; 1: Jones oxidation;
DOI:10.1016/S0039-128X(03)00085-0