4-amino-1-[2-deoxy-β-D-erythropentofuranosyl]-3-[6-(1'-benzyl-1',2',3'-triazol-4'-yl)hex-1-yn-1-yl]-1H-pyrazolo[3,4-d]pyrimidine

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Chemical Name:4-amino-1-[2-deoxy-β-D-erythropentofuranosyl]-3-[6-(1'-benzyl-1',2',3'-triazol-4'-yl)hex-1-yn-1-yl]-1H-pyrazolo[3,4-d]pyrimidine
CAS No.:1240372-00-2
Molecular Formula:C₂₅H₂₈N₈O₃
Molecular Weight:488.549
Hs Code.:

Synonyms:4-amino-1-[2-deoxy-β-D-erythropentofuranosyl]-3-[6-(1'-benzyl-1',2',3'-triazol-4'-yl)hex-1-yn-1-yl]-1H-pyrazolo[3,4-d]pyrimidine

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Chemical Property of 4-amino-1-[2-deoxy-β-D-erythropentofuranosyl]-3-[6-(1'-benzyl-1',2',3'-triazol-4'-yl)hex-1-yn-1-yl]-1H-pyrazolo[3,4-d]pyrimidine

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Technology Process of 4-amino-1-[2-deoxy-β-D-erythropentofuranosyl]-3-[6-(1'-benzyl-1',2',3'-triazol-4'-yl)hex-1-yn-1-yl]-1H-pyrazolo[3,4-d]pyrimidine

There total 8 articles about 4-amino-1-[2-deoxy-β-D-erythropentofuranosyl]-3-[6-(1'-benzyl-1',2',3'-triazol-4'-yl)hex-1-yn-1-yl]-1H-pyrazolo[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 622-79-7
benzyl azide

: 1-[2-deoxy-β-D-erythropentofuranosyl]-3-(octa-1,7-diyn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 1240372-00-2
4-amino-1-[2-deoxy-β-D-erythropentofuranosyl]-3-[6-(1'-benzyl-1',2',3'-triazol-4'-yl)hex-1-yn-1-yl]-1H-pyrazolo[3,4-d]pyrimidine

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; water; tert-butyl alcohol; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2011.07.015

Reference yield:

: 871-84-1
1,7-Octadiyne

: 1240372-00-2
4-amino-1-[2-deoxy-β-D-erythropentofuranosyl]-3-[6-(1'-benzyl-1',2',3'-triazol-4'-yl)hex-1-yn-1-yl]-1H-pyrazolo[3,4-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2: methanol; sodium methylate / 8 h / 20 °C

3: methanol; ammonia / 6 h / 100 °C / Autoclave

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tetrahydrofuran; water; tert-butyl alcohol / 12 h / 20 °C

With methanol; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(ll) sulfate pentahydrate; ammonia; sodium methylate; sodium L-ascorbate; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/bc100090y

Reference yield:

: 1240372-02-4
1-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythropentofuranosyl]-3-(octa-1,7-diyn-1-yl)-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine

: 1240372-00-2
4-amino-1-[2-deoxy-β-D-erythropentofuranosyl]-3-[6-(1'-benzyl-1',2',3'-triazol-4'-yl)hex-1-yn-1-yl]-1H-pyrazolo[3,4-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; sodium methylate / 8 h / 20 °C

2: methanol; ammonia / 6 h / 100 °C / Autoclave

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tetrahydrofuran; water; tert-butyl alcohol / 12 h / 20 °C

With methanol; copper(ll) sulfate pentahydrate; ammonia; sodium methylate; sodium L-ascorbate; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1021/bc100090y