carbonic acid 1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (1S,2S)-2-fluorocyclohexyl ester

Base Information

Chemical Name:carbonic acid 1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (1S,2S)-2-fluorocyclohexyl ester
CAS No.:1350551-45-9
Molecular Formula:C₃₉H₄₀F₂N₈O₈
Molecular Weight:786.792
Hs Code.:

carbonic acid 1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (1S,2S)-2-fluorocyclohexyl ester

Synonyms:carbonic acid 1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (1S,2S)-2-fluorocyclohexyl ester

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Chemical Property of carbonic acid 1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (1S,2S)-2-fluorocyclohexyl ester

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Technology Process of carbonic acid 1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (1S,2S)-2-fluorocyclohexyl ester

There total 4 articles about carbonic acid 1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (1S,2S)-2-fluorocyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350552-21-4
carbonic acid 1-chloroethyl ester (1S,2S)-2-fluorocyclohexyl ester

: 1350552-22-5
N-[1-amino-1-(4-{[(R)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl]amino}phenyl)methylidene]benzamide

: 1350551-45-9
carbonic acid 1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (1S,2S)-2-fluorocyclohexyl ester

Guidance literature:: With potassium hydrogencarbonate; sodium iodide; In N,N-dimethyl-formamide; at 55 ℃; for 24h;

Reference yield:

: 959-22-8
p-nitrophenylbenzoate

: 1350551-45-9
carbonic acid 1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (1S,2S)-2-fluorocyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 20 °C

2: sodium iodide; potassium hydrogencarbonate / N,N-dimethyl-formamide / 24 h / 55 °C

With potassium hydrogencarbonate; triethylamine; sodium iodide; In N,N-dimethyl-formamide;

Reference yield:

: 292150-03-9
(1S,2S)-(+)-2-fluorocyclohexanol

: 1350551-45-9
carbonic acid 1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (1S,2S)-2-fluorocyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / -78 - 20 °C

2: sodium iodide; potassium hydrogencarbonate / N,N-dimethyl-formamide / 24 h / 55 °C

With pyridine; potassium hydrogencarbonate; sodium iodide; In dichloromethane; N,N-dimethyl-formamide;