tert-butyl 1-(4-(3-(cyclopropylmethyl)-2-(methylsulfonyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Base Information

Chemical Name:tert-butyl 1-(4-(3-(cyclopropylmethyl)-2-(methylsulfonyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate
CAS No.:1301612-17-8
Molecular Formula:C₃₂H₃₅N₃O₆S
Molecular Weight:589.712
Hs Code.:

Synonyms:tert-butyl 1-(4-(3-(cyclopropylmethyl)-2-(methylsulfonyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

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Chemical Property of tert-butyl 1-(4-(3-(cyclopropylmethyl)-2-(methylsulfonyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

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Technology Process of tert-butyl 1-(4-(3-(cyclopropylmethyl)-2-(methylsulfonyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

There total 6 articles about tert-butyl 1-(4-(3-(cyclopropylmethyl)-2-(methylsulfonyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1301612-16-7
tert-butyl 1-(4-(3-(cyclopropylmethyl)-2-(methylthio)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

: 1301612-17-8
tert-butyl 1-(4-(3-(cyclopropylmethyl)-2-(methylsulfonyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: With Oxone; In tetrahydrofuran; methanol; water; at 0 - 20 ℃; for 16h;

Reference yield:

: 10428-49-6
β-chloro-β-nitrostyrene

: 1301612-17-8
tert-butyl 1-(4-(3-(cyclopropylmethyl)-2-(methylsulfonyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 96 h / Inert atmosphere; Reflux

2: N-Bromosuccinimide; potassium acetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere; Sealed tube

3: lithium hydroxide / 1,4-dioxane; water / 70 °C

4: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ISOPROPYLAMIDE / 17.17 h / 80 °C / Inert atmosphere

5: Oxone / water; tetrahydrofuran; methanol / 16 h / 0 - 20 °C

With Oxone; potassium phosphate; N-Bromosuccinimide; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;

Reference yield:

: 1301612-12-3
6-bromo-3-(cyclopropylmethyl)-2-(methylthio)-5-phenylfuro[2,3-d]pyrimidin-4(3H)-one

: 1301612-17-8
tert-butyl 1-(4-(3-(cyclopropylmethyl)-2-(methylsulfonyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ISOPROPYLAMIDE / 17.17 h / 80 °C / Inert atmosphere

2: Oxone / water; tetrahydrofuran; methanol / 16 h / 0 - 20 °C

With Oxone; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ISOPROPYLAMIDE; water;