1-benzyl 4-tert-butyl 2-((4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)succinate

Base Information

• Chemical Name: 1-benzyl 4-tert-butyl 2-((4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)succinate
• CAS No.: 1243540-11-5
• Molecular Formula: C₂₂H₃₃BO₆
• Molecular Weight: 404.311
• Mol file: 1243540-11-5.mol

Synonyms:1-benzyl 4-tert-butyl 2-((4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)succinate

Chemical Property of 1-benzyl 4-tert-butyl 2-((4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)succinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl 4-tert-butyl 2-((4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)succinate

There total 1 articles about 1-benzyl 4-tert-butyl 2-((4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

bromoacetic acid tert-butyl ester (5292-43-3) + benzyl 3-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)propanoate (1175712-34-1) → 1-benzyl 4-tert-butyl 2-((4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)succinate (1243540-11-5)

Guidance literature:

With C₄H₉Li; HN(CH(CH₃)2)2; In tetrahydrofuran; addn. of BuLi to amine deriv. in THF at -78°C for 45 min, warmingto 0°C for 10 min, addn. to boron compd. in THF at -78°C, stirring for 30 min, addn. of bromide deriv., keeping at -78°C f or 15 min, warming to 0°C; addn. of satd. aq. NH4Cl, extn. (ethyl acetate), washing with brine, drying over Na2SO4, chromy. (silica gel, 0-20% ethyl acetate in hexanes), NMR and MS;

DOI:10.1039/c004247a

upstream raw materials:

bromoacetic acid tert-butyl ester

benzyl 3-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)propanoate