(S)-(-)-SIBUTRAMINE HCL

Base Information

• Chemical Name: (S)-(-)-SIBUTRAMINE HCL
• CAS No.: 153341-23-2
• Molecular Formula: C₁₇H₂₆ClN*ClH
• Molecular Weight: 316.314
• Mol file: 153341-23-2.mol

Synonyms:Cyclobutanemethanamine,1-(4-chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)-, hydrochloride, (aS)- (9CI); (-)-Sibutramine hydrochloride

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Chemical Property of (S)-(-)-SIBUTRAMINE HCL

Chemical Property:

• PSA: 3.24000
• LogP: 5.54000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-Sibutramine Hydrochloride is a serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure.

Technology Process of (S)-(-)-SIBUTRAMINE HCL

There total 2 articles about (S)-(-)-SIBUTRAMINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sibutramine hydrochloride (84485-00-7,154752-45-1) → (-)-Sibutramine hydrochloride (153341-23-2,84485-00-7,154752-45-1) + (R)-1-(p-chlorophenyl)-α-isobutyl-N,N-dimethylcyclobutanemethylamine hydrochloride (84485-00-7,154752-45-1)

Guidance literature:

With randomly methylated β-cyclodextrin; In aq. phosphate buffer; at 15 ℃; under 22.5023 Torr; pH=4.5; Reagent/catalyst; Concentration; Temperature; enantioselective reaction; Resolution of racemate; Electrochemical reaction;

DOI:10.5935/0103-5053.20150359

Reference yield:

→ (-)-Sibutramine hydrochloride (153341-23-2,84485-00-7,154752-45-1)

Guidance literature:

upstream raw materials:

sibutramine hydrochloride

Refernces

• 1、 -. "Therapeutic agents". . . Retrieved 2008/06/13.