1-[2-(4-tert-butylphenyl)-6-[1,8]naphthyridin-2-ylpyrimidin-4-yl]ethyl ketone

Base Information

Chemical Name:1-[2-(4-tert-butylphenyl)-6-[1,8]naphthyridin-2-ylpyrimidin-4-yl]ethyl ketone
CAS No.:442128-52-1
Molecular Formula:C₂₄H₂₂N₄O
Molecular Weight:382.465
Hs Code.:

Synonyms:1-[2-(4-tert-butylphenyl)-6-[1,8]naphthyridin-2-ylpyrimidin-4-yl]ethyl ketone

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Chemical Property of 1-[2-(4-tert-butylphenyl)-6-[1,8]naphthyridin-2-ylpyrimidin-4-yl]ethyl ketone

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Technology Process of 1-[2-(4-tert-butylphenyl)-6-[1,8]naphthyridin-2-ylpyrimidin-4-yl]ethyl ketone

There total 7 articles about 1-[2-(4-tert-butylphenyl)-6-[1,8]naphthyridin-2-ylpyrimidin-4-yl]ethyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[2-(4-tert-butyl-phenyl)-6-(1-ethoxy-vinyl)-pyrimidin-4-yl]-[1,8]naphthyridine

: 442128-52-1
1-[2-(4-tert-butylphenyl)-6-[1,8]naphthyridin-2-ylpyrimidin-4-yl]ethyl ketone

Guidance literature:: With hydrogenchloride; In acetone; at 20 ℃;
DOI:10.1002/1521-3773(20020402)41:7<1195::AID-ANIE1195>3.0.CO;2-L

Reference yield:

: 7521-41-7
2-Aminonicotinaldehyde

: 442128-52-1
1-[2-(4-tert-butylphenyl)-6-[1,8]naphthyridin-2-ylpyrimidin-4-yl]ethyl ketone

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / ethanol / 4 h / Heating

2: aq. HCl / acetone / 20 °C

With hydrogenchloride; potassium hydroxide; In ethanol; acetone;
DOI:10.1002/1521-3773(20020402)41:7<1195::AID-ANIE1195>3.0.CO;2-L

Reference yield:

: 442128-03-2
2-(4-tert-butylphenyl)-4,6-dichloropyrimidine

: 442128-52-1
1-[2-(4-tert-butylphenyl)-6-[1,8]naphthyridin-2-ylpyrimidin-4-yl]ethyl ketone

Guidance literature:: Multi-step reaction with 5 steps

1: [Pd(P(C₆H₅)3)4]Cl₂ / dimethylformamide / 6 h / 80 °C

2: aq. HCl / acetone / 20 °C

3: [Pd(P(C₆H₅)3)4]Cl₂ / dimethylformamide / 6 h / 80 °C

4: KOH / ethanol / 4 h / Heating

5: aq. HCl / acetone / 20 °C

With hydrogenchloride; potassium hydroxide; tetrakis(triphenylphosphine)palladium dichloride; In ethanol; N,N-dimethyl-formamide; acetone; 1: Stille coupling reaction / 3: Stille coupling reaction;
DOI:10.1002/1521-3773(20020402)41:7<1195::AID-ANIE1195>3.0.CO;2-L