methyl 2-(3,4-dichlorophenyl)-4-(6-fluoro-2-oxo-1,2-dihydro-1'H-spiro[3,1-benzoxazine-4,4'-piperidin]-1'-yl)butanoate

Base Information

Chemical Name:methyl 2-(3,4-dichlorophenyl)-4-(6-fluoro-2-oxo-1,2-dihydro-1'H-spiro[3,1-benzoxazine-4,4'-piperidin]-1'-yl)butanoate
CAS No.:1036926-69-8
Molecular Formula:C₂₃H₂₃Cl₂FN₂O₄
Molecular Weight:481.351
Hs Code.:

Synonyms:methyl 2-(3,4-dichlorophenyl)-4-(6-fluoro-2-oxo-1,2-dihydro-1'H-spiro[3,1-benzoxazine-4,4'-piperidin]-1'-yl)butanoate

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Chemical Property of methyl 2-(3,4-dichlorophenyl)-4-(6-fluoro-2-oxo-1,2-dihydro-1'H-spiro[3,1-benzoxazine-4,4'-piperidin]-1'-yl)butanoate

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Technology Process of methyl 2-(3,4-dichlorophenyl)-4-(6-fluoro-2-oxo-1,2-dihydro-1'H-spiro[3,1-benzoxazine-4,4'-piperidin]-1'-yl)butanoate

There total 2 articles about methyl 2-(3,4-dichlorophenyl)-4-(6-fluoro-2-oxo-1,2-dihydro-1'H-spiro[3,1-benzoxazine-4,4'-piperidin]-1'-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1036926-74-5
2-(3,4-dichloro-phenyl)-4-oxo-butyric acid methyl ester

: 92926-32-4
6-fluorospiro[3,1-benzoxazine-4,4'-piperidin]-2(1h)-one

: 1036926-69-8
methyl 2-(3,4-dichlorophenyl)-4-(6-fluoro-2-oxo-1,2-dihydro-1'H-spiro[3,1-benzoxazine-4,4'-piperidin]-1'-yl)butanoate

Guidance literature:: 2-(3,4-dichloro-phenyl)-4-oxo-butyric acid methyl ester; 6-fluorospiro[3,1-benzoxazine-4,4'-piperidin]-2(1h)-one; With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; at 20 ℃; for 16h;

With water; sodium carbonate; In tetrahydrofuran; Product distribution / selectivity;

Reference yield: 18.0%

: 1036926-67-6
4-bromo-2-(3,4-dichloro-phenyl)-butyric acid methyl ester

: 1036926-61-0
6-fluorospiro[3,1-benzoxazine-4,4'-piperidin]-2(1H)-one hydrochloride

: 1036926-69-8
methyl 2-(3,4-dichlorophenyl)-4-(6-fluoro-2-oxo-1,2-dihydro-1'H-spiro[3,1-benzoxazine-4,4'-piperidin]-1'-yl)butanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Product distribution / selectivity;

Reference yield:

: 1036926-69-8
methyl 2-(3,4-dichlorophenyl)-4-(6-fluoro-2-oxo-1,2-dihydro-1'H-spiro[3,1-benzoxazine-4,4'-piperidin]-1'-yl)butanoate

: 1036926-71-2
2-(3,4-dichlorophenyl)-4-(6-fluoro-2-oxo-1,2-dihydro-1'H-spiro[3,1-benzoxazine-4,4'-piperidin]-1'-yl)butanoic acid hydrochloride

Guidance literature:: methyl 2-(3,4-dichlorophenyl)-4-(6-fluoro-2-oxo-1,2-dihydro-1'H-spiro[3,1-benzoxazine-4,4'-piperidin]-1'-yl)butanoate; With lithium hydroxide; water; In tetrahydrofuran; for 2h; Heating / reflux;

With hydrogenchloride; water; Product distribution / selectivity;