Benzyloxy-acetic acid (S)-1-{(E)-2-[(4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-vinyl}-4-methyl-pentyl ester

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Chemical Name:Benzyloxy-acetic acid (S)-1-{(E)-2-[(4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-vinyl}-4-methyl-pentyl ester
CAS No.:863453-38-7
Molecular Formula:C₄₀H₅₄O₆Si
Molecular Weight:658.951
Hs Code.:

Benzyloxy-acetic acid (S)-1-{(E)-2-[(4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-vinyl}-4-methyl-pentyl ester

Synonyms:Benzyloxy-acetic acid (S)-1-{(E)-2-[(4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-vinyl}-4-methyl-pentyl ester

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Chemical Property of Benzyloxy-acetic acid (S)-1-{(E)-2-[(4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-vinyl}-4-methyl-pentyl ester

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Technology Process of Benzyloxy-acetic acid (S)-1-{(E)-2-[(4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-vinyl}-4-methyl-pentyl ester

There total 6 articles about Benzyloxy-acetic acid (S)-1-{(E)-2-[(4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-vinyl}-4-methyl-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 863453-34-3
(E)-3-((4S,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-acrylic acid methyl ester

: 863453-38-7
Benzyloxy-acetic acid (S)-1-{(E)-2-[(4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-vinyl}-4-methyl-pentyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / imidazole / dimethylformamide / 3 h / 20 °C

2: 96 percent / DIBAL-H / CH₂Cl₂ / 4 h / -78 °C

3: 91 percent / MnO₂ / CH₂Cl₂ / 20 h / 20 °C

4: 25 percent / tetrahydrofuran / 1 h / -78 °C

5: 82 percent / PPh₃; DIAD / tetrahydrofuran / 3.5 h / 0 - 20 °C

With 1H-imidazole; manganese(IV) oxide; di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 5: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2005.05.065

Reference yield:

: 863453-51-4
(E)-3-[(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-methyl-prop-2-en-1-ol

: 863453-38-7
Benzyloxy-acetic acid (S)-1-{(E)-2-[(4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-vinyl}-4-methyl-pentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / MnO₂ / CH₂Cl₂ / 20 h / 20 °C

2: 25 percent / tetrahydrofuran / 1 h / -78 °C

3: 82 percent / PPh₃; DIAD / tetrahydrofuran / 3.5 h / 0 - 20 °C

With manganese(IV) oxide; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; dichloromethane; 3: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2005.05.065

Reference yield:

: 863453-35-4
(E)-3-[(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-methyl-propenal

: 863453-38-7
Benzyloxy-acetic acid (S)-1-{(E)-2-[(4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-vinyl}-4-methyl-pentyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 25 percent / tetrahydrofuran / 1 h / -78 °C

2: 82 percent / PPh₃; DIAD / tetrahydrofuran / 3.5 h / 0 - 20 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 2: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2005.05.065