(+/-)-N-hydroxy-N-[2,3-dihydro-6-(benzyloxy)benzofuran-3-yl]urea

Base Information

• Chemical Name: (+/-)-N-hydroxy-N-[2,3-dihydro-6-(benzyloxy)benzofuran-3-yl]urea
• CAS No.: 184575-08-4
• Molecular Formula: C₁₆H₁₆N₂O₄
• Molecular Weight: 300.314
• Mol file: 184575-08-4.mol

Synonyms:(+/-)-N-hydroxy-N-[2,3-dihydro-6-(benzyloxy)benzofuran-3-yl]urea

Chemical Property of (+/-)-N-hydroxy-N-[2,3-dihydro-6-(benzyloxy)benzofuran-3-yl]urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-N-hydroxy-N-[2,3-dihydro-6-(benzyloxy)benzofuran-3-yl]urea

There total 2 articles about (+/-)-N-hydroxy-N-[2,3-dihydro-6-(benzyloxy)benzofuran-3-yl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

trimethylsilyl isocyanate (1118-02-1) + N-[6-Benzyloxy-2,3-dihydrobenzofuran-3-yl]-hydroxylamine (139149-23-8) → (+/-)-N-hydroxy-N-[2,3-dihydro-6-(benzyloxy)benzofuran-3-yl]urea (184575-08-4)

Guidance literature:

In tetrahydrofuran; at 55 ℃;

DOI:10.1021/jm960271d

Reference yield:

(E/Z)-6-benzyloxy-2,3-dihydrobenzofuran-3-oxime (139149-22-7) → (+/-)-N-hydroxy-N-[2,3-dihydro-6-(benzyloxy)benzofuran-3-yl]urea (184575-08-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / BH₃*Py, HCl / methanol; CH₂Cl₂ / Ambient temperature

2: 53 percent / tetrahydrofuran / 55 °C

With hydrogenchloride; borane pyridine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/jm960271d

Reference yield:

(S)-4-benzyloxazolidin-2-one-3-carbonyl chloride (139149-49-8) + (+/-)-N-hydroxy-N-[2,3-dihydro-6-(benzyloxy)benzofuran-3-yl]urea (184575-08-4) → C27H25N3O7 (1026190-77-1) + C27H25N3O7

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)73875-5

upstream raw materials:

trimethylsilyl isocyanate

N-[6-Benzyloxy-2,3-dihydrobenzofuran-3-yl]-hydroxylamine

(E/Z)-6-benzyloxy-2,3-dihydrobenzofuran-3-oxime

Downstream raw materials:

C₂₇H₂₅N₃O₇