Dimethyl 2-<2'-<3''-furanyl>-1'-(N^b-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>propanedioate

Base Information

• Chemical Name: Dimethyl 2-<2'-<3''-furanyl>-1'-(N^b-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>propanedioate
• CAS No.: 153275-91-3
• Molecular Formula: C₂₇H₂₆N₂O₅
• Molecular Weight: 458.514

Synonyms:Dimethyl 2-<2'-<3''-furanyl>-1'-(N^b-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>propanedioate

Chemical Property of Dimethyl 2-<2'-<3''-furanyl>-1'-(N^b-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>propanedioate

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Technology Process of Dimethyl 2-<2'-<3''-furanyl>-1'-(N^b-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>propanedioate

There total 2 articles about Dimethyl 2-<2'-<3''-furanyl>-1'-(N^b-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

furan-3-carboxaldehyde (498-60-2) + Dimethyl 2-<3-<2-b-(phenylmethyl)amino>ethyl>indolyl>propanedioate (153275-90-2) → Dimethyl 2-<2'-<3''-furanyl>-1'-(Nb-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>propanedioate (153275-91-3)

Guidance literature:

With molecular sieve; boron trifluoride diethyl etherate; In benzene; for 24h; Heating;

DOI:10.1021/jo00078a029

Reference yield:

Dimethyl 2-<3-<2-b,Nb-bis(phenylmethyl)amino>ethyl>indolyl>propanedioate (153275-89-9) → Dimethyl 2-<2'-<3''-furanyl>-1'-(Nb-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>propanedioate (153275-91-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / H₂ / 10percent Pd/C / acetic acid

2: 52 percent / BF₃*etherate, molecular sieve / benzene / 24 h / Heating

With molecular sieve; boron trifluoride diethyl etherate; hydrogen; palladium on activated charcoal; In acetic acid; benzene;

DOI:10.1021/jo00078a029

Reference yield: 34.0%

Dimethyl 2-<2'-<3''-furanyl>-1'-(Nb-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>propanedioate (153275-91-3) → Methyl 3-(phenylmethyl)-4-(3'-furanyl)-1,2,3,4,5,6-hexahydroazepino<4,5-b>indole-5-carboxylate

Guidance literature:

With triethylamine hydrochloride; lithium chloride; In N,N-dimethyl acetamide; at 130 ℃; for 3.5h;

DOI:10.1021/jo00078a029

upstream raw materials:

furan-3-carboxaldehyde

Dimethyl 2-<3-<2-b-(phenylmethyl)amino>ethyl>indolyl>propanedioate

Dimethyl 2-<3-<2-b,N^b-bis(phenylmethyl)amino>ethyl>indolyl>propanedioate

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