ETHYL 4-HYDROXY-8-METHOXYQUINALDATE

Base Information

• Chemical Name: ETHYL 4-HYDROXY-8-METHOXYQUINALDATE
• CAS No.: 55895-59-5
• Molecular Formula: C13H13NO4
• Molecular Weight: 247.251
• Mol file: 55895-59-5.mol

Synonyms:4-HYDROXY-8-METHOXY-QUINOLINE-2-CARBOXYLIC ACID ETHYL ESTER;ETHYL 4-HYDROXY-8-METHOXYQUINALDATE;ETHYL 4-HYDROXY-8-METHOXYQUINOLINE-2-CARBOXYLATE

Chemical Property of ETHYL 4-HYDROXY-8-METHOXYQUINALDATE

Chemical Property:

• PSA: 68.65000
• LogP: 2.12570

Purity/Quality:

98%min ^*data from raw suppliers

ETHYL 4-HYDROXY-8-METHOXY-2-QUINOLINECARBOXYLATE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-HYDROXY-8-METHOXYQUINALDATE

There total 6 articles about ETHYL 4-HYDROXY-8-METHOXYQUINALDATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H19NO5 (911808-80-5) → Ethyl 1,4-dihydro-8-methoxy-4-oxo-quinoline-2-carboxylate (128233-26-1,55895-59-5)

Guidance literature:

With polyphosphoric acid; In neat (no solvent); at 135 ℃; for 2h;

DOI:10.1021/jo3025626

Reference yield:

o-anisidino-butenedioic acid diethyl ester → 8-methoxy-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid ethyl ester (55895-59-5)

Guidance literature:

Reference yield:

2-methoxy-phenylamine (90-04-0) → Ethyl 1,4-dihydro-8-methoxy-4-oxo-quinoline-2-carboxylate (128233-26-1,55895-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 4 h / 20 °C

2: polyphosphoric acid / neat (no solvent) / 2 h / 135 °C

With polyphosphoric acid; In methanol; 1: |Michael Addition;

DOI:10.1021/jo3025626

upstream raw materials:

4-hydroxy-8-methoxy-quinoline-2-carboxylic acid

2-methoxy-phenylamine

C₁₅H₁₉NO₅

acetylenedicarboxylic acid diethyl ester

Downstream raw materials:

xanthurenic acid

4-hydroxy-8-methoxy-quinoline-2-carboxylic acid

Ethyl 4-chloro-8-methoxy-2-quinoline carboxylate

ethyl 2-(2-chloropyridin-3-yl)acetate