ethyl 3-{4-[2-(5-acetylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

Base Information

• Chemical Name: ethyl 3-{4-[2-(5-acetylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate
• CAS No.: 1433194-93-4
• Molecular Formula: C₂₅H₂₉NO₅
• Molecular Weight: 423.509
• Mol file: 1433194-93-4.mol

Synonyms:ethyl 3-{4-[2-(5-acetylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

Chemical Property of ethyl 3-{4-[2-(5-acetylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-{4-[2-(5-acetylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

There total 4 articles about ethyl 3-{4-[2-(5-acetylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

1-(1H-indol-5-yl)ethanone (53330-94-2) + ethyl 3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-propionate (901113-92-6) → ethyl 3-{4-[2-(5-acetylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate (1433194-93-4)

Guidance literature:

1-(1H-indol-5-yl)ethanone; With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

ethyl 3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-propionate; In N,N-dimethyl-formamide; for 15h; Reflux;

DOI:10.1002/cmdc.201200316

Reference yield:

C15H19ClO4 → ethyl 3-{4-[2-(5-acetylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate (1433194-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen; palladium 10% on activated carbon / ethanol / 20 h / 20 °C / 760.05 Torr

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

2.2: 15 h / Reflux

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201200316

Reference yield:

5-bromo-1H-indole (10075-50-0) → ethyl 3-{4-[2-(5-acetylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate (1433194-93-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

1.2: 0.33 h / -78 °C

2.1: tetrahydrofuran; mineral oil; pentane / -78 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

3.2: 15 h / Reflux

With potassium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; pentane;

DOI:10.1002/cmdc.201200316

upstream raw materials:

1-(1H-indol-5-yl)ethanone

ethyl 3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-propionate

5-bromo-1H-indole

Downstream raw materials:

ethyl 2-ethoxy-3-{4-[2-(5-{1-[E-phenoxyimino]ethyl}indol-1-yl)ethoxy]phenyl}propionate

ethyl 2-ethoxy-3-{4-[2-(5-{1-[E-benzyloxyimino]ethyl}indol-1-yl)ethoxy]phenyl}propionate

ethyl 2-ethoxy-3-{4-[2-(5-{1-[E-cyclopropylmethoxyimino]ethyl}indol-1-yl)ethoxy]phenyl}propionate

ethyl 2-ethoxy-3-{4-[2-(5-{1-[E-cyclohexyloxyimino]ethyl}indol-1-yl)ethoxy]phenyl}propionate