(S)-toluene-4-sulfonic acid isopropylcarbamoyl-phenyl-methyl ester

Base Information

• Chemical Name: (S)-toluene-4-sulfonic acid isopropylcarbamoyl-phenyl-methyl ester
• CAS No.: 1354039-87-4
• Molecular Formula: C₁₈H₂₁NO₄S
• Molecular Weight: 347.435
• Mol file: 1354039-87-4.mol

Synonyms:(S)-toluene-4-sulfonic acid isopropylcarbamoyl-phenyl-methyl ester

Chemical Property of (S)-toluene-4-sulfonic acid isopropylcarbamoyl-phenyl-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (S)-toluene-4-sulfonic acid isopropylcarbamoyl-phenyl-methyl ester

There total 2 articles about (S)-toluene-4-sulfonic acid isopropylcarbamoyl-phenyl-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-α-hydroxy-N-isopropyl-2-phenylacetamide (89843-36-7) + p-toluenesulfonyl chloride (98-59-9) → (S)-toluene-4-sulfonic acid isopropylcarbamoyl-phenyl-methyl ester (1354039-87-4)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield:

(S)-Mandelic acid (17199-29-0) → (S)-toluene-4-sulfonic acid isopropylcarbamoyl-phenyl-methyl ester (1354039-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide; 1-hydroxy-pyrrolidine-2,5-dione / tetrahydrofuran / 48 h / 0 - 20 °C

2: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C

With dmap; 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

Reference yield:

(S)-toluene-4-sulfonic acid isopropylcarbamoyl-phenyl-methyl ester (1354039-87-4) + (S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3.4-tetrahydroisoquinoline hydrochloride (54417-52-6,66820-84-6) → (R)-2-[(S)-(1-3,4-dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-isopropyl-2-phenylacetamide (1354039-86-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In butanone; at 70 ℃; for 48h;

upstream raw materials:

(S)-α-hydroxy-N-isopropyl-2-phenylacetamide

p-toluenesulfonyl chloride

(S)-Mandelic acid

Downstream raw materials:

(R)-2-[(S)-(1-3,4-dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-isopropyl-2-phenylacetamide